![](/images/graphics-bg.png)
Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin
Joint Authors
Hamada, Hiroki
Park, Jeongmin
Park, Hyeok-Jun
Jekal, Seung-Joo
Sato, Daisuke
Chen, Yingqing
Joe, Yeonsoo
Chung, Hun Taeg
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Pterostilbene, a dimethyl ester analog of resveratrol, has anti-inflammatory and antioxidative effects and alters cell proliferation.
Tristetraprolin (TTP) promotes the degradation of proinflammatory mediators via binding to adenosine and uridine- (AU-) rich elements (ARE) located in the 3′-untranslated regions of mRNAs.
Here, we utilized pterostilbene 4′-β-glucoside (4-PG), a compound derived from pterostilbene, to investigate whether it has anti-inflammatory effects on dextran sulfate sodium- (DSS-) induced colitis via TTP enhancement.
TTP expression was increased in 4-PG dose- and time-dependent manners in RAW264.7 cells.
The production of proinflammatory cytokine, such as TNF-α, was reduced by 4-PG in vitro.
To investigate the role of TTP in the anti-inflammatory effects of 4-PG, we used DSS-induced colitis in TTP WT and KO mice as models.
The expression levels of TTP and proinflammatory cytokines were determined in serum and colon tissue.
4-PG increased the expression of TTP while suppressing proinflammatory cytokines both in vitro and in vivo.
These findings suggest that treatment with 4-PG mediates the anti-inflammatory effects of 4-PG on DSS-induced colitis via enhancing TTP expression.
American Psychological Association (APA)
Chen, Yingqing& Park, Jeongmin& Joe, Yeonsoo& Park, Hyeok-Jun& Jekal, Seung-Joo& Sato, Daisuke…[et al.]. 2017. Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196523
Modern Language Association (MLA)
Chen, Yingqing…[et al.]. Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1196523
American Medical Association (AMA)
Chen, Yingqing& Park, Jeongmin& Joe, Yeonsoo& Park, Hyeok-Jun& Jekal, Seung-Joo& Sato, Daisuke…[et al.]. Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196523