NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial IschemiaReperfusion Injury in Diabetic Rats
المؤلفون المشاركون
Wu, Yang
Zhou, Bin
Meng, Qing-Tao
Zhao, Bo
Leng, Yan
Liu, Min
Qiu, Zhen
Lei, Shao-Qing
Su, Wating
Xia, Zhong-Yuan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-14
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
The reactive oxygen species- (ROS-) induced nod-like receptor protein-3 (NLRP3) inflammasome triggers sterile inflammatory responses and pyroptosis, which is a proinflammatory form of programmed cell death initiated by the activation of inflammatory caspases.
NLRP3 inflammasome activation plays an important role in myocardial ischemia/reperfusion (MI/R) injury.
Our present study investigated whether diabetes aggravated MI/R injury through NLRP3 inflammasome-mediated pyroptosis.
Type 1 diabetic rat model was established by intraperitoneal injection of streptozotocin (60 mg/kg).
MI/R was induced by ligating the left anterior descending artery (LAD) for 30 minutes followed by 2 h reperfusion.
H9C2 cardiomyocytes were exposed to high glucose (HG, 30 mM) conditions and hypoxia/reoxygenation (H/R) stimulation.
The myocardial infarct size, CK-MB, and LDH release in the diabetic rats subjected to MI/R were significantly higher than those in the nondiabetic rats, accompanied with increased NLRP3 inflammasome activation and increased pyroptosis.
Inhibition of inflammasome activation with BAY11-7082 significantly decreased the MI/R injury.
In vitro studies showed similar effects, as BAY11-7082 or the ROS scavenger N-acetylcysteine, attenuated HG and H/R-induced H9C2 cell injury.
In conclusion, hyperglycaemia-induced NLRP3 inflammasome activation may be a ROS-dependent process in pyroptotic cell death, and NLRP3 inflammasome-induced pyroptosis aggravates MI/R injury in diabetic rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qiu, Zhen& Lei, Shao-Qing& Zhao, Bo& Wu, Yang& Su, Wating& Liu, Min…[et al.]. 2017. NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial IschemiaReperfusion Injury in Diabetic Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1196688
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qiu, Zhen…[et al.]. NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial IschemiaReperfusion Injury in Diabetic Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1196688
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qiu, Zhen& Lei, Shao-Qing& Zhao, Bo& Wu, Yang& Su, Wating& Liu, Min…[et al.]. NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial IschemiaReperfusion Injury in Diabetic Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1196688
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196688
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر