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Salidroside Inhibits HMGB1 Acetylation and Release through Upregulation of SirT1 during Inflammation
المؤلفون المشاركون
Zhang, Yao
Qi, Shimei
Li, Qiang
Qi, Zhilin
Ling, Liefeng
Gui, Lin
Yan, Liang
Lv, Jun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
HMGB1, a highly conserved nonhistone DNA-binding protein, plays an important role in inflammatory diseases.
Once released to the extracellular space, HMGB1 acts as a proinflammatory cytokine that triggers inflammatory reaction.
Our previous study showed that salidroside exerts anti-inflammatory effect via inhibiting the JAK2-STAT3 signalling pathway.
However, whether salidroside inhibits the release of HMGB1 is still unclear.
In this study, we aim to study the effects of salidroside on HMGB1 release and then investigate the potential molecular mechanisms.
In an experimental rat model of sepsis caused by CLP, salidroside administration significantly attenuated lung injury and reduced the serum HMGB1 level.
In RAW264.7 cells, we investigated the effects of salidroside on LPS-induced HMGB1 release and then explored the underlying molecular mechanisms.
We found that salidroside significantly inhibited LPS-induced HMGB1 release, and the inhibitory effect was correlated with the HMGB1 acetylation levels.
Mechanismly, salidroside inhibits HMGB1 acetylation through the AMPK-SirT1 pathway.
In addition, SirT1 overexpression attenuated LPS-induced HMGB1 acetylation and nucleocytoplasmic translocation.
Furthermore, in SirT1 shRNA plasmid-transfected cells, salidroside treatment enhanced SirT1 expression and reduced LPS-activated HMGB1 acetylation and nucleocytoplasmic translocation.
Collectively, these results demonstrated that salidroside might reduce HMGB1 release through the AMPK-SirT1 signalling pathway and suppress HMGB1 acetylation and nucleocytoplasmic translocation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qi, Zhilin& Zhang, Yao& Qi, Shimei& Ling, Liefeng& Gui, Lin& Yan, Liang…[et al.]. 2017. Salidroside Inhibits HMGB1 Acetylation and Release through Upregulation of SirT1 during Inflammation. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1196743
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qi, Zhilin…[et al.]. Salidroside Inhibits HMGB1 Acetylation and Release through Upregulation of SirT1 during Inflammation. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1196743
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qi, Zhilin& Zhang, Yao& Qi, Shimei& Ling, Liefeng& Gui, Lin& Yan, Liang…[et al.]. Salidroside Inhibits HMGB1 Acetylation and Release through Upregulation of SirT1 during Inflammation. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1196743
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196743
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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