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Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV-Infected Individuals: A Longitudinal Study
المؤلفون المشاركون
Correa, C. R.
Tasca, Karen Ingrid
Caleffi, Juliana Trindade
Gatto, Mariana
Camargo, Caio Cavassan de
Biasin, Mara
Souza, Lenice do Rosário de
Tavares, Francilene Capel
Sartori, Alexandrina
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
The combination antiretroviral therapy (cART) increases the oxidative stress in HIV-infected people, which in turn favors the onset and aggravation of non-AIDS comorbidities, a common situation affecting these individuals.
We aimed to evaluate the influence of cART initiation on oxidative stress parameters.
This is a longitudinal study including 30 asymptomatic patients divided according to their CD4+ T cell count (G1: <500 cell/mL; G2: >500 cell/mL) before (M0) and after (M1) cART initiation.
We analyzed total antioxidant capacity (TAC), fat-soluble vitamins, malondialdehyde, 8-isoprostane, and DNA damage.
Results.
Results showed a decrease in TAC, retinol, α-tocopherol, and some carotenoids, in addition to a significant increase in DNA damage at M1.
These changes were more evident in G2 subjects.
Moreover, there was a significant 8-isoprostane increase at M1 in individuals belonging to G1.
Conclusion.
The results indicate that cART interfered in the redox system, mainly by reducing the antioxidant defenses.
In addition, patients who had CD4+ T counts higher than 500 cells/mm3 showed more susceptibility to genotoxicity, while patients with less CD4+ T counts displayed more damage triggered by lipoperoxidation.
Considering the early beginning of cART, its chronic use, and its capacity to alter the redox status, further long-term studies on larger cohorts are needed to define the best time to initiate therapy and to investigate new strategies to delay the development of non-AIDS diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tasca, Karen Ingrid& Caleffi, Juliana Trindade& Correa, C. R.& Gatto, Mariana& Tavares, Francilene Capel& Camargo, Caio Cavassan de…[et al.]. 2017. Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV-Infected Individuals: A Longitudinal Study. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196751
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tasca, Karen Ingrid…[et al.]. Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV-Infected Individuals: A Longitudinal Study. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1196751
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tasca, Karen Ingrid& Caleffi, Juliana Trindade& Correa, C. R.& Gatto, Mariana& Tavares, Francilene Capel& Camargo, Caio Cavassan de…[et al.]. Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV-Infected Individuals: A Longitudinal Study. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196751
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196751
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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