Effects of Oral Supplementation with Docosahexaenoic Acid (DHA) plus Antioxidants in Pseudoexfoliative Glaucoma: A 6-Month Open-Label Randomized Trial
المؤلفون المشاركون
Domingo, Joan Carles
Romeo Villadóniga, Stéphanie
Rodríguez García, Elena
Sagastagoia Epelde, Olatz
Álvarez Díaz, M. Dolores
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
To assess the effects of antioxidant oral supplementation based on docosahexaenoic acid (DHA) in pseudoexfoliative (PEX) glaucoma.
Patients and Methods.
A prospective 6-month open-label randomized controlled trial was conducted in patients with PEX glaucoma and adequate intraocular pressure (IOP) control.
Patients in the DHA group received a high-rich DHA (1 g) nutraceutical formulation.
Ophthalmological examination, DHA erythrocyte membrane content (% total fatty acids), plasma total antioxidant capacity (TAC), plasma malondialdehyde (MDA), and plasma IL-6 levels were assessed.
Results.
Forty-seven patients (DHA group 23, controls 24; mean age 70.3 years) were included.
In the DHA group, the mean IOP in the right eye decreased from 14.7 [3.3] mmHg at baseline to 12.1 [1.5] mmHg at 6 months (P=0.01).
In the left eye, IOP decreased from 15.1 [3.3] mmHg at baseline to 12.2 [2.4] mmHg at 6 months (P=0.007).
DHA erythrocyte content increased in the DHA group, with significant differences versus controls at 3 months and 6 months (8.1% [0.9] vs.
4.4% [0.7]; P<0.0001).
At 6 months and in the DHA group only, TAC levels as compared with baseline increased significantly (919.7 [117.9] vs.
856.9 [180.3] µM copper-reducing equivalents; P=0.01), and both MDA (4.4 [0.8] vs.
5.2 [1.1] nmol/mL; P = 0.02) and IL-6 (2.8 [1.3] vs.
4.7 [2.3] pg/mL; P=0.006) levels were lower than in controls.
Conclusions.
Targeting pathophysiology mechanisms of PEX glaucoma by reducing oxidative stress and inflammation with a high-rich DHA supplement might be an attractive therapeutic approach.
Despite the short duration of treatment, decrease in IOP supports the clinical significance of DHA supplementation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Romeo Villadóniga, Stéphanie& Rodríguez García, Elena& Sagastagoia Epelde, Olatz& Álvarez Díaz, M. Dolores& Domingo, Joan Carles. 2018. Effects of Oral Supplementation with Docosahexaenoic Acid (DHA) plus Antioxidants in Pseudoexfoliative Glaucoma: A 6-Month Open-Label Randomized Trial. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1196966
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Romeo Villadóniga, Stéphanie…[et al.]. Effects of Oral Supplementation with Docosahexaenoic Acid (DHA) plus Antioxidants in Pseudoexfoliative Glaucoma: A 6-Month Open-Label Randomized Trial. Journal of Ophthalmology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1196966
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Romeo Villadóniga, Stéphanie& Rodríguez García, Elena& Sagastagoia Epelde, Olatz& Álvarez Díaz, M. Dolores& Domingo, Joan Carles. Effects of Oral Supplementation with Docosahexaenoic Acid (DHA) plus Antioxidants in Pseudoexfoliative Glaucoma: A 6-Month Open-Label Randomized Trial. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1196966
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196966
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر