LRRK2 G2019S Mutation: Prevalence and Clinical Features in Moroccans with Parkinson’s Disease
المؤلفون المشاركون
Ben El Haj, Rafiqua
Regragui, Wafaa
Skalli, Asmae
Bouslam, Naima
Benomar, Ali
Yahyaoui, Mohamed
Bouhouche, Ahmed
Tibar, Houyam
El Bayad, Khalil
Razine, Rachid
Tazrout, Sanaa
Elouardi, Loubna
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The LRRK2 G2019S mutation is the most common genetic determinant of Parkinson’s disease (PD) identified to date.
This mutation, reported in both familial and sporadic PD, occurs at elevated frequencies in Maghreb population.
In the present study, we examined the prevalence of the G2019S mutation in the Moroccan population and we compared the motor and nonmotor phenotype of G2019S carriers to patients with idiopathic Parkinson’s disease.
Methods.
100 PD patients were assessed for motor and nonmotor symptoms, current medication, and motor complication including motor fluctuations and dyskinesia.
The LRRK2 G2019S mutation was investigated by direct sequencing in patients and ethnically matched controls, all of Moroccan origin.
Results.
Among the 100 PD Moroccan patients, 41 (41%) were carriers of the G2019S mutation.
The mutation frequency was higher among probands with autosomal dominant inheritance (76%) than among sporadic ones (28%).
Interestingly, G2019S mutation was also found in 5% of control individuals.
Clinically, patients carrying the G2019S mutation have more dystonia (OR = 4.6, p = 0.042) and more sleep disorders (OR = 2.4, p = 0.045) than noncarriers.
Conclusions.
The LRRK2 G2019S prevalence in Morocco is the highest in the world reported to date.
Some clinical features in G2019S carriers such as dystonia and sleep disturbances are worth noting.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bouhouche, Ahmed& Tibar, Houyam& Ben El Haj, Rafiqua& El Bayad, Khalil& Razine, Rachid& Tazrout, Sanaa…[et al.]. 2017. LRRK2 G2019S Mutation: Prevalence and Clinical Features in Moroccans with Parkinson’s Disease. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1196979
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bouhouche, Ahmed…[et al.]. LRRK2 G2019S Mutation: Prevalence and Clinical Features in Moroccans with Parkinson’s Disease. Parkinson’s Disease No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1196979
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bouhouche, Ahmed& Tibar, Houyam& Ben El Haj, Rafiqua& El Bayad, Khalil& Razine, Rachid& Tazrout, Sanaa…[et al.]. LRRK2 G2019S Mutation: Prevalence and Clinical Features in Moroccans with Parkinson’s Disease. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1196979
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196979
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر