Genetic Variants in SNCA and the Risk of Sporadic Parkinson’s Disease and Clinical Outcomes: A Review
المؤلفون المشاركون
Campêlo, Clarissa Loureiro das Chagas
Silva, Regina Helena
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
There is increasing evidence of the contribution of genetic susceptibility to the etiology of Parkinson’s disease (PD).
Genetic variations in the SNCA gene are well established by linkage and genome-wide association studies.
Positive associations of single nucleotide polymorphisms (SNPs) in SNCA and increased risk for PD were found.
However, the role of SNCA variants in individual traits or phenotypes of PD is unknown.
Here, we reviewed the current literature and identified 57 studies, performed in fourteen different countries, that investigated SNCA variants and susceptibility to PD.
We discussed the findings based on environmental factors, history of PD, clinical outcomes, and ethnicity.
In conclusion, SNPs within the SNCA gene can modify the susceptibility to PD, leading to increased or decreased risk.
The risk associations of some SNPs varied among samples.
Of notice, no studies in South American or African populations were found.
There is little information about the effects of these variants on particular clinical aspects of PD, such as motor and nonmotor symptoms.
Similarly, evidence of possible interactions between SNCA SNPs and environmental factors or disease progression is scarce.
There is a need to expand the clinical applicability of these data as well as to investigate the role of SNCA SNPs in populations with different ethnic backgrounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Campêlo, Clarissa Loureiro das Chagas& Silva, Regina Helena. 2017. Genetic Variants in SNCA and the Risk of Sporadic Parkinson’s Disease and Clinical Outcomes: A Review. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1197053
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Campêlo, Clarissa Loureiro das Chagas& Silva, Regina Helena. Genetic Variants in SNCA and the Risk of Sporadic Parkinson’s Disease and Clinical Outcomes: A Review. Parkinson’s Disease No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1197053
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Campêlo, Clarissa Loureiro das Chagas& Silva, Regina Helena. Genetic Variants in SNCA and the Risk of Sporadic Parkinson’s Disease and Clinical Outcomes: A Review. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1197053
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197053
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر