Identification of NURR1 (Exon 4) and FOXA1 (Exon 3) Haplotypes Associated with mRNA Expression Levels in Peripheral Blood Lymphocytes of Parkinson’s Patients in Small Indian Population
المؤلفون المشاركون
Nellore, Jayshree
Tippabathani, Jayakrishna
Radhakrishnan, Vaishnavie
Banik, Somashree
Kapoor, Sonia
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Here, we study the expression of NURR1 and FOXA1 mRNA in peripheral blood lymphocytes and its haplotypes in coding region in a small Chennai population of India.
Thirty cases of Parkinson’s patients (PD) with anti-PD medications (20 males aged 65.85±1.19 and 10 females aged 65.7±1.202) and 30 age matched healthy people (20 males aged 68.45±1.282 and 10 females aged 65.8±1.133) were included.
The expression of NURR1 and FOXA1 in PBL was detected by Q-PCR and haplotypes were identified by PCR-SSCP.
In the 30 PD cases examined, NURR1 and FOXA1 expression was significantly reduced in both male and female PD patients.
However, NURR1 (57.631% reduced in males; 28.93% in females) and FOXA1 (64.42% in males; 55.76% in females) mRNA expression did differ greatly between male and female PD patients.
Polymorphisms were identified at exon 4 of the NURR1 and at exon 3 of the FOXA1, respectively, in both male and female patients.
A near significant difference in SSCP patterns between genders of control and PD population was analyzed suggesting that further investigations of more patients, more molecular markers, and coding regions should be performed.
Such studies could potentially reveal peripheral molecular marker of early PD and different significance to the respective genders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tippabathani, Jayakrishna& Nellore, Jayshree& Radhakrishnan, Vaishnavie& Banik, Somashree& Kapoor, Sonia. 2017. Identification of NURR1 (Exon 4) and FOXA1 (Exon 3) Haplotypes Associated with mRNA Expression Levels in Peripheral Blood Lymphocytes of Parkinson’s Patients in Small Indian Population. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197089
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tippabathani, Jayakrishna…[et al.]. Identification of NURR1 (Exon 4) and FOXA1 (Exon 3) Haplotypes Associated with mRNA Expression Levels in Peripheral Blood Lymphocytes of Parkinson’s Patients in Small Indian Population. Parkinson’s Disease No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1197089
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tippabathani, Jayakrishna& Nellore, Jayshree& Radhakrishnan, Vaishnavie& Banik, Somashree& Kapoor, Sonia. Identification of NURR1 (Exon 4) and FOXA1 (Exon 3) Haplotypes Associated with mRNA Expression Levels in Peripheral Blood Lymphocytes of Parkinson’s Patients in Small Indian Population. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197089
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197089
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر