Interactions between PPAR Gamma and the Canonical WntBeta-Catenin Pathway in Type 2 Diabetes and Colon Cancer

المؤلفون المشاركون

Lecarpentier, Yves
Vallée, Alexandre
Hébert, Jean-Louis
Claes, Victor

المصدر

PPAR Research

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-02-19

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأحياء

الملخص EN

In both colon cancer and type 2 diabetes, metabolic changes induced by upregulation of the Wnt/beta-catenin signaling and downregulation of peroxisome proliferator-activated receptor gamma (PPAR gamma) may help account for the frequent association of these two diseases.

In both diseases, PPAR gamma is downregulated while the canonical Wnt/beta-catenin pathway is upregulated.

In colon cancer, upregulation of the canonical Wnt system induces activation of pyruvate dehydrogenase kinase and deactivation of the pyruvate dehydrogenase complex.

As a result, a large part of cytosolic pyruvate is converted into lactate through activation of lactate dehydrogenase.

Lactate is extruded out of the cell by means of activation of monocarboxylate lactate transporter-1.

This phenomenon is called Warburg effect.

PPAR gamma agonists induce beta-catenin inhibition, while inhibition of the canonical Wnt/beta-catenin pathway activates PPAR gamma.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Lecarpentier, Yves& Claes, Victor& Vallée, Alexandre& Hébert, Jean-Louis. 2017. Interactions between PPAR Gamma and the Canonical WntBeta-Catenin Pathway in Type 2 Diabetes and Colon Cancer. PPAR Research،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197250

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Lecarpentier, Yves…[et al.]. Interactions between PPAR Gamma and the Canonical WntBeta-Catenin Pathway in Type 2 Diabetes and Colon Cancer. PPAR Research No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1197250

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Lecarpentier, Yves& Claes, Victor& Vallée, Alexandre& Hébert, Jean-Louis. Interactions between PPAR Gamma and the Canonical WntBeta-Catenin Pathway in Type 2 Diabetes and Colon Cancer. PPAR Research. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197250

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1197250