2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis
المؤلفون المشاركون
Bionaz, Massimo
Rosa, Fernanda
Osorio, Johan S.
Trevisi, Erminio
Yanqui-Rivera, Francisco
Estill, Charles T.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-22، 22ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-27
دولة النشر
مصر
عدد الصفحات
22
التخصصات الرئيسية
الملخص EN
Mastitis is a major disease in dairy cows resulting in significant economic losses.
In vitro works suggest that ruminants peroxisome proliferator-activated receptor gamma (PPARγ) can aid in improving the response to mastitis and can control milk fat synthesis.
The objectives of the present experiment were to test if treatment with the putative PPARγ agonist 2,4-thiazolidinedione (TZD) improves (1) the response to subclinical mastitis and (2) milk fat production.
Lactating goats received daily injections of 8 mg/kg BW of TZD or saline for 3 weeks.
After one week of TZD injection, half of the goats in each group received intramammary infusion of Strep.
uberis or saline in both halves for a total of 4 groups (n=6/group).
TZD treatment did not affect milk fat but had positive effect on milk somatic cells count, blood nonesterified fatty acids, inflammatory markers, and liver function.
TZD significantly increased myeloperoxidase but did not affect leukocytes phagocytosis or insulin.
TZD increased adipocytes size and had minor effect on expression of PPARγ target genes in mammary epithelial cells but not in adipose tissue.
Overall, TZD ameliorated the response to intramammary infection but the effect on milk fat synthesis and expression of related transcripts was less than expected.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rosa, Fernanda& Osorio, Johan S.& Trevisi, Erminio& Yanqui-Rivera, Francisco& Estill, Charles T.& Bionaz, Massimo. 2017. 2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis. PPAR Research،Vol. 2017, no. 2017, pp.1-22.
https://search.emarefa.net/detail/BIM-1197275
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rosa, Fernanda…[et al.]. 2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis. PPAR Research No. 2017 (2017), pp.1-22.
https://search.emarefa.net/detail/BIM-1197275
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rosa, Fernanda& Osorio, Johan S.& Trevisi, Erminio& Yanqui-Rivera, Francisco& Estill, Charles T.& Bionaz, Massimo. 2,4-Thiazolidinedione Treatment Improves the Innate Immune Response in Dairy Goats with Induced Subclinical Mastitis. PPAR Research. 2017. Vol. 2017, no. 2017, pp.1-22.
https://search.emarefa.net/detail/BIM-1197275
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197275
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر