Noradrenaline, Serotonin, GABA, and Glycine in Cerebrospinal Fluid during Labor Pain: A Cross-Sectional Prospective Study
المؤلفون المشاركون
Honsawek, Sittisak
Chalermkitpanit, Pornpan
Thonnagith, Atikun
Engsusophon, Phatthanaphol
Charuluxananan, Somrat
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background and Aims.
The inhibitory pathways that play a role in spinal modulation include local interneurons and descending control.
Clinical data regarding the role of these pathways in acute pain is lacking.
Accordingly, the aim of this study was to evaluate cerebrospinal fluid (CSF) levels of noradrenaline, serotonin, gamma-aminobutyric acid (GABA), and glycine in parturients with labor pain compared to those without labor pain.
Methods.
One hundred term uncomplicated pregnant women receiving spinal anesthesia for cesarean section were enrolled in this prospective cross-sectional study.
CSF noradrenaline, serotonin, GABA, and glycine levels were analyzed by enzyme-linked immunosorbent assay.
Labor pain score was assessed by numerical rating scale.
Results.
Median CSF serotonin concentration in parturients with labor pain was significantly lower than in those without pain (p<0.001).
Median CSF glycine level in the labor pain group was significantly higher than in the control group (p<0.001).
There were no significant differences in median CSF level of noradrenaline or GABA between parturients with and without labor pain.
Subsequent analysis showed labor pain scores to be negatively correlated with CSF serotonin (r=-0.217, p=0.04) but positively correlated with CSF glycine (r=0.415, p<0.001).
Conclusion.
CSF serotonin and glycine were significantly correlated with labor pain scores.
These findings suggest that the serotonergic and glycinergic systems may play a role in spinal modulation of visceral pain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chalermkitpanit, Pornpan& Thonnagith, Atikun& Engsusophon, Phatthanaphol& Charuluxananan, Somrat& Honsawek, Sittisak. 2017. Noradrenaline, Serotonin, GABA, and Glycine in Cerebrospinal Fluid during Labor Pain: A Cross-Sectional Prospective Study. Pain Research and Management،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197360
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chalermkitpanit, Pornpan…[et al.]. Noradrenaline, Serotonin, GABA, and Glycine in Cerebrospinal Fluid during Labor Pain: A Cross-Sectional Prospective Study. Pain Research and Management No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1197360
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chalermkitpanit, Pornpan& Thonnagith, Atikun& Engsusophon, Phatthanaphol& Charuluxananan, Somrat& Honsawek, Sittisak. Noradrenaline, Serotonin, GABA, and Glycine in Cerebrospinal Fluid during Labor Pain: A Cross-Sectional Prospective Study. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197360
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197360
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر