Intravenous Oxycodone versus Intravenous Morphine in Cancer Pain: A Randomized, Open-Label, Parallel-Group, Active-Control Study
المؤلفون المشاركون
Lee, Kyung-Hee
Kang, Jung-Hun
Oh, Ho-Suk
Choi, Moon-Ki
Shim, Byoung-Yong
Eum, Young-Jun
Park, Hye-Jeong
Kang, Jin-Hyong
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-31
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
To compare efficacy and safety of intravenous continuous infusion of oxycodone with morphine in patients with cancer pain.
Methods.
A 5-day, randomized, open-label, exploratory study at 6 sites in the Republic of Korea.
Sixty-six adults aged ≥19 years with moderate-to-severe cancer pain (Numeric Rating Scale [NRS] ≥ 4) were enrolled.
The study group received intravenous (IV) oxycodone, and the comparator group received IV morphine which were titrated depending on pain intensity.
The efficacy endpoint is change in average NRS score from baseline to Day 5.
Other assessments included worst, current, and average pain intensity; patient satisfaction; medication dose; and adverse events.
Results.
Both groups achieved >50% reduction in average pain intensity: from “moderate” at baseline (oxycodone versus morphine: 6.0 ± 1.8 versus 5.9 ± 1.4) to “mild” at Day 5 (2.5 ± 1.8 versus 2.8 ± 1.6).
While this reduction was similar between groups (3.5 ± 2.2 versus 3.1 ± 1.8, P value = 0.562), oxycodone achieved faster pain relief (average pain: 3.0 ± 1.6 versus 3.9 ± 1.6, P value = 0.020) on Day 2 and significant NRS reductions for worst pain on Day 2 (P value = 0.045) and current pain on Day 2 (P value = 0.035) and Day 5 (P value = 0.020) compared to morphine.
Patient satisfaction, adverse events, and adverse drug reactions were similar for both groups.
Conclusions.
For Asian patients with cancer pain, IV oxycodone is faster acting and showed similar analgesic efficacy and safety profiles as IV morphine.
This trial is registered with Clinicaltrials.gov NCT02660229.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Kyung-Hee& Kang, Jung-Hun& Oh, Ho-Suk& Choi, Moon-Ki& Shim, Byoung-Yong& Eum, Young-Jun…[et al.]. 2017. Intravenous Oxycodone versus Intravenous Morphine in Cancer Pain: A Randomized, Open-Label, Parallel-Group, Active-Control Study. Pain Research and Management،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1197551
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Kyung-Hee…[et al.]. Intravenous Oxycodone versus Intravenous Morphine in Cancer Pain: A Randomized, Open-Label, Parallel-Group, Active-Control Study. Pain Research and Management No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1197551
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Kyung-Hee& Kang, Jung-Hun& Oh, Ho-Suk& Choi, Moon-Ki& Shim, Byoung-Yong& Eum, Young-Jun…[et al.]. Intravenous Oxycodone versus Intravenous Morphine in Cancer Pain: A Randomized, Open-Label, Parallel-Group, Active-Control Study. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1197551
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197551
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر