Early Evidence of Cardiotoxicity and Tumor Response in Patients with Sarcomas after High Cumulative Dose Doxorubicin Given as a Continuous Infusion
المؤلفون المشاركون
Ravi, Vinod
Araujo, Dejka M.
Somaiah, Neeta
Conley, Anthony
Quintana, Raymundo A.
Benjamin, Robert S.
Lin, Heather
Gupta, Ridhi
Raj, Sean D.
Vadhan-Raj, Saroj
Patel, Shreyaskumar
Banchs, Jose
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Despite the dose-dependent response rate of sarcomas to doxorubicin, clinicians limit its cumulative dose due to cardiotoxicity.
This study evaluates early evidence of cardiotoxicity in patients treated with high-dose doxorubicin given as a continuous infusion.
Methods.
Data was collected on patients who received 90 mg/m2 doxorubicin as a continuous infusion and 10 gm/m2 ifosfamide for up to 6 cycles as part of a phase II study.
Cardiotoxicity was assessed with serial echocardiograms or multigated acquisition scans and serum brain natriuretic peptide and troponin levels.
Tumor responses were determined by serial radiographic imaging per RECIST.
Result.
Out of the 48 patients enrolled, no patient developed heart failure symptoms; however, 4 out of the 38 (10%) patients with serial left ventricular ejection fraction assessments developed subclinical cardiotoxicity (asymptomatic drop in LVEF ≥ 10%).
Twenty-three patients received all six 72-hour cycles of doxorubicin with a mean cumulative dose of 540 mg/m2.
Among these patients, 4% (n=1) developed subclinical cardiotoxicity.
In the advanced disease group (n=39), patients with a complete or partial response received a higher mean cumulative dose than those with stable disease (p<0.033).
Conclusions.
Doxorubicin cardiotoxicity can be limited by administering doxorubicin as a continuous infusion, allowing higher cumulative dosing to maximize efficacy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Quintana, Raymundo A.& Banchs, Jose& Gupta, Ridhi& Lin, Heather& Raj, Sean D.& Conley, Anthony…[et al.]. 2017. Early Evidence of Cardiotoxicity and Tumor Response in Patients with Sarcomas after High Cumulative Dose Doxorubicin Given as a Continuous Infusion. Complexity،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197743
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Quintana, Raymundo A.…[et al.]. Early Evidence of Cardiotoxicity and Tumor Response in Patients with Sarcomas after High Cumulative Dose Doxorubicin Given as a Continuous Infusion. Complexity No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1197743
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Quintana, Raymundo A.& Banchs, Jose& Gupta, Ridhi& Lin, Heather& Raj, Sean D.& Conley, Anthony…[et al.]. Early Evidence of Cardiotoxicity and Tumor Response in Patients with Sarcomas after High Cumulative Dose Doxorubicin Given as a Continuous Infusion. Complexity. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1197743
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197743
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر