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Periodontal Ligament Stem Cells in the Periodontitis Microenvironment Are Sensitive to Static Mechanical Strain
المؤلفون المشاركون
Qin, Wen
Liu, Jia
Jin, Zuolin
Liu, Shiyu
Gao, Jie
Song, Yang
Li, Qiang
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-21
دولة النشر
مصر
عدد الصفحات
13
الملخص EN
During orthodontic treatment, periodontium remodeling of periodontitis patients under mechanical force was abnormal.
We have previously confirmed the function impairment of periodontal ligament stem cells (PDLSCs) in the periodontitis microenvironment which might be involved in this pathological process.
However, the response of PDLSCs in periodontitis microenvironment to mechanical force remains unclear.
Therefore, in the present study, we introduced a Flexcell tension apparatus and investigated the response of PDLSCs obtained from periodontal tissues of periodontitis patients (PPDLSCs) and of those obtained from healthy periodontal tissues (HPDLSCs) to different magnitudes of static mechanical strain (SMS).
PPDLSCs showed increased proliferation, decreased osteogenic activity, activated osteoclastogenesis, and greater secretion of inflammatory cytokines.
Different magnitudes of SMS exerted distinct effects on HPDLSCs and PPDLSCs.
An SMS of 12% induced optimal effects in HPDLSCs, including the highest proliferation, the best osteogenic ability, the lowest osteoclastogenesis, and the lowest secretion of inflammatory cytokines, while the optimal SMS for PPDLSCs was 8%.
Excessive SMS damaged PPDLSCs function, including decreased proliferation, an imbalance between osteogenesis and osteoclastogenesis, and an activated inflammatory response.
Our data suggest that PPDLSCs are more sensitive and less tolerant to SMS, and this may explain why mechanical force results in undesirable effects in periodontitis patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Jia& Li, Qiang& Liu, Shiyu& Gao, Jie& Qin, Wen& Song, Yang…[et al.]. 2017. Periodontal Ligament Stem Cells in the Periodontitis Microenvironment Are Sensitive to Static Mechanical Strain. Stem Cells International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1200627
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Jia…[et al.]. Periodontal Ligament Stem Cells in the Periodontitis Microenvironment Are Sensitive to Static Mechanical Strain. Stem Cells International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1200627
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Jia& Li, Qiang& Liu, Shiyu& Gao, Jie& Qin, Wen& Song, Yang…[et al.]. Periodontal Ligament Stem Cells in the Periodontitis Microenvironment Are Sensitive to Static Mechanical Strain. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1200627
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1200627
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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