Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes
المؤلفون المشاركون
Tao, Kai
Guo, Bingyu
Chang, Peng
Hui, Qiang
Shi, Jie
Liang, Jiulong
Zhang, Yu
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-04
دولة النشر
مصر
عدد الصفحات
17
الملخص EN
Articular cartilage injury and defect caused by trauma and chronic osteoarthritis vascularity are very common, while the repair of injured cartilage remains a great challenge due to its limited healing capacity.
Stem cell-based tissue engineering provides a promising treatment option for injured articular cartilage because of the cells potential for multiple differentiations.
However, its application has been largely limited by stem cell type, number, source, proliferation, and differentiation.
We hypothesized that (1) adipose-derived stem cells are ideal seed cells for articular cartilage repair because of their accessibility and abundance and (2) the microenvironment of articular cartilage could induce adipose-derived stem cells (ADSCs) to differentiate into chondrocytes.
In order to test our hypotheses, we isolated stem cells from rabbit adipose tissues and cocultured these ADSCs with rabbit articular cartilage chondrocytes.
We found that when ADSCs were cocultured with chondrocytes, the proliferation of articular cartilage chondrocytes was promoted, the apoptosis of chondrocytes was inhibited, and the osteogenic and chondrogenic differentiation of ADSCs was enhanced.
The study on the mechanism of this coculture system indicated that the role of this coculture system is similar to the function of TGF-β1 in the promotion of chondrocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Jie& Liang, Jiulong& Guo, Bingyu& Zhang, Yu& Hui, Qiang& Chang, Peng…[et al.]. 2017. Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes. Stem Cells International،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1200802
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Jie…[et al.]. Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes. Stem Cells International No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1200802
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Jie& Liang, Jiulong& Guo, Bingyu& Zhang, Yu& Hui, Qiang& Chang, Peng…[et al.]. Adipose-Derived Stem Cells Cocultured with Chondrocytes Promote the Proliferation of Chondrocytes. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1200802
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1200802
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر