Intracortical Administration of the Complement C3 Receptor Antagonist Trifluoroacetate Modulates Microglia Reaction after Brain Injury
المؤلفون المشاركون
Hermann, Dirk M.
Surugiu, Roxana
Catalin, Bogdan
Dumbrava, Danut
Gresita, Andrei
Olaru, Denisa Greta
Popa-Wagner, Aurel
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Worldwide, millions of individuals suffer an ischemic stroke each year, causing major disability, especially in the elderly, where stroke is the number one cause of disability.
However, to date, no effective therapy exists that targets the functional recovery after stroke.
After necrosis, neuroinflammation is a common feature of the acute stroke and a major obstacle to tissue restoration.
In the lesioned area, the dying neurons release chemotactic signals, such as fractalkine/CX3CL1, which evoke “eat-me” signals that are recognized by microglia expressing complement C3a receptor (C3aR), resulting in phagocytosis of the dying but still viable neurons, known as secondary phagocytosis.
Using a mouse model of stroke and two-photon microscopy, we aimed to attenuate poststroke phagocytosis of the dying but still viable neurons by using SB 290157, an antagonist of C3aR.
We found that intracortical administration of SB 290157 reduced the number of inflammatory microglial cells expressing ED1 and Iba1 antigens at the lesion site.
We could show, in vivo, that two days after a needle-induced cortical lesion there were less microglial cells present around the injury site, displaying less high-order branches and an increase in the lower order ones, suggesting an attenuated phagocytic phenotype in treated animals as compared with controls.
We conclude that the C3aR antagonist, SB 290157, may be used in the future to limit the neuronal death by limiting secondary phagocytosis after stroke.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Surugiu, Roxana& Catalin, Bogdan& Dumbrava, Danut& Gresita, Andrei& Olaru, Denisa Greta& Hermann, Dirk M.…[et al.]. 2019. Intracortical Administration of the Complement C3 Receptor Antagonist Trifluoroacetate Modulates Microglia Reaction after Brain Injury. Neural Plasticity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1200961
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Surugiu, Roxana…[et al.]. Intracortical Administration of the Complement C3 Receptor Antagonist Trifluoroacetate Modulates Microglia Reaction after Brain Injury. Neural Plasticity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1200961
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Surugiu, Roxana& Catalin, Bogdan& Dumbrava, Danut& Gresita, Andrei& Olaru, Denisa Greta& Hermann, Dirk M.…[et al.]. Intracortical Administration of the Complement C3 Receptor Antagonist Trifluoroacetate Modulates Microglia Reaction after Brain Injury. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1200961
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1200961
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر