Mahuang-Fuzi-Xixin Decoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis
المؤلفون المشاركون
Dai, Guoliang
Jing, Wen
Song, Shanshan
Sun, Hong
Chen, Ying
Zhao, Quan
Zhang, You
Ju, Wenzheng
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-11
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Evidence suggests that inflammation and neurogenesis play an important role in major depressive disorder (MDD).
Mahuang-Fuzi-Xixin decoction (MFX), as the traditional Chinese prescription, has been widely applied for asthma, migraine, and MDD in clinics.
However, the effects of MFX on the potential mechanism in MDD are still unclear.
Hence, the present study is aimed at exploring whether the antidepressive effect of MFX is connected to the anti-inflammatory and promoting neurogenesis.
Besides, lipopolysaccharide (LPS) of Gram-negative bacteria can induce depressive-like behaviors.
We demonstrated that administration of MFX corrected the depressive-like behaviors in LPS-induced mice and significantly decreased the expression of IL-1β in the hippocampus.
LPS injection induced a significant increase in the levels of NLRP3, cleaved caspase-1 p20, and ASC in the hippocampus, as well as Trx-interacting protein (TXNIP), and MFX could reverse this change.
What is more, treatment of MFX increased the level of doublecortin (DCX), brain-derived neurotrophic factor (BDNF), and tropomyosin-related kinase receptor B (TrkB) in the hippocampus which means that MFX could promote the neurogenesis.
In conclusion, the study indicates that MFX relieves a depressive-like state in LPS-induced mice through the inhibition of the NLRP3 inflammasome and the enhancement of the neurogenesis pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jing, Wen& Song, Shanshan& Sun, Hong& Chen, Ying& Zhao, Quan& Zhang, You…[et al.]. 2019. Mahuang-Fuzi-Xixin Decoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis. Neural Plasticity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1200993
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jing, Wen…[et al.]. Mahuang-Fuzi-Xixin Decoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis. Neural Plasticity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1200993
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jing, Wen& Song, Shanshan& Sun, Hong& Chen, Ying& Zhao, Quan& Zhang, You…[et al.]. Mahuang-Fuzi-Xixin Decoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1200993
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1200993
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر