Classification of Visual Cortex Plasticity Phenotypes following Treatment for Amblyopia
المؤلفون المشاركون
Balsor, Justin L.
Jones, David G.
Murphy, Kathryn M.
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-03
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
Monocular deprivation (MD) during the critical period (CP) has enduring effects on visual acuity and the functioning of the visual cortex (V1).
This experience-dependent plasticity has become a model for studying the mechanisms, especially glutamatergic and GABAergic receptors, that regulate amblyopia.
Less is known, however, about treatment-induced changes to those receptors and if those changes differentiate treatments that support the recovery of acuity versus persistent acuity deficits.
Here, we use an animal model to explore the effects of 3 visual treatments started during the CP (n=24, 10 male and 14 female): binocular vision (BV) that promotes good acuity versus reverse occlusion (RO) and binocular deprivation (BD) that causes persistent acuity deficits.
We measured the recovery of a collection of glutamatergic and GABAergic receptor subunits in the V1 and modeled recovery of kinetics for NMDAR and GABAAR.
There was a complex pattern of protein changes that prompted us to develop an unbiased data-driven approach for these high-dimensional data analyses to identify plasticity features and construct plasticity phenotypes.
Cluster analysis of the plasticity phenotypes suggests that BV supports adaptive plasticity while RO and BD promote a maladaptive pattern.
The RO plasticity phenotype appeared more similar to adults with a high expression of GluA2, and the BD phenotypes were dominated by GABAAα1, highlighting that multiple plasticity phenotypes can underlie persistent poor acuity.
After 2-4 days of BV, the plasticity phenotypes resembled normals, but only one feature, the GluN2A:GluA2 balance, returned to normal levels.
Perhaps, balancing Hebbian (GluN2A) and homeostatic (GluA2) mechanisms is necessary for the recovery of vision.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Balsor, Justin L.& Jones, David G.& Murphy, Kathryn M.. 2019. Classification of Visual Cortex Plasticity Phenotypes following Treatment for Amblyopia. Neural Plasticity،Vol. 2019, no. 2019, pp.1-23.
https://search.emarefa.net/detail/BIM-1201068
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Balsor, Justin L.…[et al.]. Classification of Visual Cortex Plasticity Phenotypes following Treatment for Amblyopia. Neural Plasticity No. 2019 (2019), pp.1-23.
https://search.emarefa.net/detail/BIM-1201068
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Balsor, Justin L.& Jones, David G.& Murphy, Kathryn M.. Classification of Visual Cortex Plasticity Phenotypes following Treatment for Amblyopia. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-23.
https://search.emarefa.net/detail/BIM-1201068
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201068
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر