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Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APPPS1 Double Transgenic Mice
المؤلفون المشاركون
Xu, Anping
Li, Zhigang
Zhou, You
Guo, Yu
Tang, Yinshan
Shao, Shujun
Cao, Jin
Wu, Jihong
Xiang, Dulian
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Increased amyloid-β (Aβ) plaque deposition is thought to be the main cause of Alzheimer’s disease (AD).
β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is the key protein involved in Aβ peptide generation.
Excessive expression of BACE1 might cause overproduction of neurotoxins in the central nervous system.
Previous studies indicated that BACE1 initially cleaves the amyloid precursor protein (APP) and may subsequently interfere with physiological functions of proteins such as PKA, which is recognized to be closely associated with long-term potentiation (LTP) level and can effectively ameliorate cognitive impairments.
Therefore, revealing the underlying mechanism of BACE1 in the pathogenesis of AD might have a significant impact on the future development of therapeutic agents targeting dementia.
This study examined the effects of electroacupuncture (EA) stimulation on BACE1, APP, and p-PKA protein levels in hippocampal tissue samples.
Memory and learning abilities were assessed using the Morris water maze test after EA intervention.
Immunofluorescence, immunohistochemistry, and western blot were employed to assess the distribution patterns and expression levels of BACE1, APP, and p-PKA, respectively.
The results showed the downregulation of BACE1 and APP and the activation of PKA by EA.
In summary, EA treatment might reduce BACE1 deposition in APP/PS1 transgenic mice and regulate PKA and its associated substrates, such as LTP to change memory and learning abilities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Yinshan& Shao, Shujun& Guo, Yu& Zhou, You& Cao, Jin& Xu, Anping…[et al.]. 2019. Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APPPS1 Double Transgenic Mice. Neural Plasticity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1201097
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Yinshan…[et al.]. Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APPPS1 Double Transgenic Mice. Neural Plasticity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1201097
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Yinshan& Shao, Shujun& Guo, Yu& Zhou, You& Cao, Jin& Xu, Anping…[et al.]. Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APPPS1 Double Transgenic Mice. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1201097
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201097
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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