Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren’s Syndrome
المؤلفون المشاركون
Hamrah, Pedram
Aluri, Hema S.
Samizadeh, Mahta
Edman, Maria C.
Hawley, Dillon R.
Armaos, Helene L.
Janga, Srikanth R.
Meng, Zhen
Sendra, Victor G.
Kublin, Claire L.
Hamm-Alvarez, Sarah F.
Zoukhri, Driss
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-02
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
The purpose of the present study was to test the potential of mouse bone marrow-derived mesenchymal stem cells (BD-MSCs) in improving tear production in a mouse model of Sjögren’s syndrome dry eye and to investigate the underlying mechanisms involved.
NOD mice (n=20) were randomized to receive i.p.
injection of sterile phosphate buffered saline (PBS, control) or murine BD-MSCs (1 × 106 cells).
Tears production was measured at baseline and once a week after treatment using phenol red impregnated threads.
Cathepsin S activity in the tears was measured at the end of treatment.
After 4 weeks, animals were sacrificed and the lacrimal glands were excised and processed for histopathology, immunohistochemistry, and RNA analysis.
Following BD-MSC injection, tears production increased over time when compared to both baseline and PBS injected mice.
Although the number of lymphocytic foci in the lacrimal glands of treated animals did not change, the size of the foci decreased by 40.5% when compared to control animals.
The mRNA level of the water channel aquaporin 5 was significantly increased following delivery of BD-MSCs.
We conclude that treatment with BD-MSCs increases tear production in the NOD mouse model of Sjögren’s syndrome.
This is likely due to decreased inflammation and increased expression of aquaporin 5.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aluri, Hema S.& Samizadeh, Mahta& Edman, Maria C.& Hawley, Dillon R.& Armaos, Helene L.& Janga, Srikanth R.…[et al.]. 2017. Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren’s Syndrome. Stem Cells International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1201119
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aluri, Hema S.…[et al.]. Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren’s Syndrome. Stem Cells International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1201119
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aluri, Hema S.& Samizadeh, Mahta& Edman, Maria C.& Hawley, Dillon R.& Armaos, Helene L.& Janga, Srikanth R.…[et al.]. Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren’s Syndrome. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1201119
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201119
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر