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Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy
المؤلفون المشاركون
Soares, Milena Botelho
Ribeiro-dos-Santos, Ricardo
Souza, Bruno Solano de Freitas
Silva, Kátia Nunes da
Silva, Daniela Nascimento
Rocha, Vinícius Pinto Costa
Paredes, Bruno Diaz
Azevedo, Carine Machado
Nonaka, Carolina Kymie
Carvalho, Gisele Batista
Vasconcelos, Juliana Fraga
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-10
دولة النشر
مصر
عدد الصفحات
13
الملخص EN
Therapies based on transplantation of mesenchymal stromal cells (MSC) hold promise for the management of inflammatory disorders.
In chronic Chagas disease cardiomyopathy (CCC), caused by chronic infection with Trypanosoma cruzi, the exacerbated immune response plays a critical pathophysiological role and can be modulated by MSC.
Here, we investigated the role of galectin-3 (Gal-3), a beta-galactoside-binding lectin with several actions on immune responses and repair process, on the immunomodulatory potential of MSC.
Gal-3 knockdown in MSC did not affect the immunophenotype or differentiation potential.
However, Gal-3 knockdown MSC showed decreased proliferation, survival, and migration.
Additionally, when injected intraperitoneally into mice with CCC, Gal-3 knockdown MSC showed impaired migration in vivo.
Transplantation of control MSC into mice with CCC caused a suppression of cardiac inflammation and fibrosis, reducing expression levels of CD45, TNFα, IL-1β, IL-6, IFNγ, and type I collagen.
In contrast, Gal-3 knockdown MSC were unable to suppress the immune response or collagen synthesis in the hearts of mice with CCC.
Finally, infection with T.
cruzi demonstrated parasite survival in wild-type but not in Gal-3 knockdown MSC.
These findings demonstrate that Gal-3 plays a critical role in MSC survival, proliferation, migration, and therapeutic potential in CCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Souza, Bruno Solano de Freitas& Silva, Kátia Nunes da& Silva, Daniela Nascimento& Rocha, Vinícius Pinto Costa& Paredes, Bruno Diaz& Azevedo, Carine Machado…[et al.]. 2017. Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy. Stem Cells International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1201168
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Souza, Bruno Solano de Freitas…[et al.]. Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy. Stem Cells International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1201168
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Souza, Bruno Solano de Freitas& Silva, Kátia Nunes da& Silva, Daniela Nascimento& Rocha, Vinícius Pinto Costa& Paredes, Bruno Diaz& Azevedo, Carine Machado…[et al.]. Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1201168
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201168
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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