Enhancement of Anti-Inflammatory and Osteogenic Abilities of Mesenchymal Stem Cells via Cell-to-Cell Adhesion to Periodontal Ligament-Derived Fibroblasts

المؤلفون المشاركون

Suzuki, Keita
Chosa, Naoyuki
Sawada, Shunsuke
Takizawa, Naoki
Yaegashi, Takashi
Ishisaki, Akira

المصدر

Stem Cells International

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-01-12

دولة النشر

مصر

عدد الصفحات

12

الملخص EN

Mesenchymal stem cells (MSCs) are involved in anti-inflammatory events and tissue repair; these functions are activated by their migration or homing to inflammatory tissues in response to various chemokines.

However, the mechanism by which MSCs interact with other cell types in inflammatory tissue remains unclear.

We investigated the role of periodontal ligament fibroblasts (PDL-Fs) in regulating the anti-inflammatory and osteogenic abilities of bone marrow-derived- (BM-) MSCs.

The expression of monocyte chemotactic protein- (MCP-)1 was significantly enhanced by stimulation of PDL-Fs with inflammatory cytokines.

MCP-1 induced the migratory ability of BM-MSCs but not PDL-Fs.

Expression levels of anti-inflammatory and inflammatory cytokines were increased and decreased, respectively, by direct-contact coculture between MSCs and PDL-Fs.

In addition, the direct-contact coculture enhanced the expression of MSC markers that play important roles in the self-renewal and maintenance of multipotency of MSCs, which in turn induced the osteogenic ability of the cells.

These results suggest that MCP-1 induces the migration and homing of BM-MSCs into the PDL inflammatory tissue.

The subsequent adherence of MSCs to PDL-Fs plays an immunomodulatory role to terminate inflammation during wound healing and upregulates the expression stem cell markers to enhance the stemness of MSCs, thereby facilitating bone formation in damaged PDL tissue.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Suzuki, Keita& Chosa, Naoyuki& Sawada, Shunsuke& Takizawa, Naoki& Yaegashi, Takashi& Ishisaki, Akira. 2017. Enhancement of Anti-Inflammatory and Osteogenic Abilities of Mesenchymal Stem Cells via Cell-to-Cell Adhesion to Periodontal Ligament-Derived Fibroblasts. Stem Cells International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1201174

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Suzuki, Keita…[et al.]. Enhancement of Anti-Inflammatory and Osteogenic Abilities of Mesenchymal Stem Cells via Cell-to-Cell Adhesion to Periodontal Ligament-Derived Fibroblasts. Stem Cells International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1201174

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Suzuki, Keita& Chosa, Naoyuki& Sawada, Shunsuke& Takizawa, Naoki& Yaegashi, Takashi& Ishisaki, Akira. Enhancement of Anti-Inflammatory and Osteogenic Abilities of Mesenchymal Stem Cells via Cell-to-Cell Adhesion to Periodontal Ligament-Derived Fibroblasts. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1201174

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1201174