Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats
المؤلفون المشاركون
Liu, Hao-Li
Huang, Ying-Zu
Chen, Hsin-Yung
Hsieh, Tsung-Hsun
Liu, Hui-hua
Peng, Chih-Wei
Pei, Yu-Cheng
He, Xiao-Kuo
Juan, Chi-Hung
Feng, Xiao-Jun
Wang, Jia-Yi
Rotenberg, Alexander
Chiang, Yung-Hsiao
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Transcranial direct current stimulation (tDCS) is a noninvasive technique for modulating neural plasticity and is considered to have therapeutic potential in neurological disorders.
For the purpose of translational neuroscience research, a suitable animal model can be ideal for providing a stable condition for identifying mechanisms that can help to explore therapeutic strategies.
Here, we developed a tDCS protocol for modulating motor excitability in anesthetized rats.
To examine the responses of tDCS-elicited plasticity, the motor evoked potential (MEP) and MEP input-output (IO) curve elicited by epidural motor cortical electrical stimulus were evaluated at baseline and after 30 min of anodal tDCS or cathodal tDCS.
Furthermore, a paired-pulse cortical electrical stimulus was applied to assess changes in the inhibitory network by measuring long-interval intracortical inhibition (LICI) before and after tDCS.
In the results, analogous to those observed in humans, the present study demonstrates long-term potentiation- (LTP-) and long-term depression- (LTD-) like plasticity can be induced by tDCS protocol in anesthetized rats.
We found that the MEPs were significantly enhanced immediately after anodal tDCS at 0.1 mA and 0.8 mA and remained enhanced for 30 min.
Similarly, MEPs were suppressed immediately after cathodal tDCS at 0.8 mA and lasted for 30 min.
No effect was noted on the MEP magnitude under sham tDCS stimulation.
Furthermore, the IO curve slope was elevated following anodal tDCS and presented a trend toward diminished slope after cathodal tDCS.
No significant differences in the LICI ratio of pre- to post-tDCS were observed.
These results indicated that developed tDCS schemes can produce consistent, rapid, and controllable electrophysiological changes in corticomotor excitability in rats.
This newly developed tDCS animal model could be useful to further explore mechanical insights and may serve as a translational platform bridging human and animal studies, establishing new therapeutic strategies for neurological disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Hui-hua& He, Xiao-Kuo& Chen, Hsin-Yung& Peng, Chih-Wei& Rotenberg, Alexander& Juan, Chi-Hung…[et al.]. 2019. Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats. Neural Plasticity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1201212
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Hui-hua…[et al.]. Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats. Neural Plasticity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1201212
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Hui-hua& He, Xiao-Kuo& Chen, Hsin-Yung& Peng, Chih-Wei& Rotenberg, Alexander& Juan, Chi-Hung…[et al.]. Neuromodulatory Effects of Transcranial Direct Current Stimulation on Motor Excitability in Rats. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1201212
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201212
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر