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Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment
المؤلفون المشاركون
Libien, Jenny
Hernández, A. Iván
Regier, Matthew
Liang, Jiancong
Choi, Alexander
Verma, Kavita
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that regulates gene expression through poly(ADP)-ribosylation, resulting in the loosening of chromatin structure.
PARP-1 enzymatic activity has been shown to be necessary for the expression of several genes required for memory formation and consolidation.
Previously, we showed that nucleolar PARP-1 is significantly decreased in hippocampal pyramidal cells in Alzheimer’s disease (AD).
We proposed that the displacement of PARP-1 from the nucleolus results in downregulation of new rRNA expression and ribosome biogenesis, leading to cognitive impairment.
To further investigate the relationship between nucleolar PARP-1 and memory impairment, we examined PARP-1 expression in the hippocampi of individuals with mild cognitive impairment (MCI) compared to control and AD cases.
We used immunohistochemical techniques to examine the nucleolar distribution of PARP-1 in the Cornu Ammonis (CA region) of the hippocampus.
PARP-1 positive cells were then scored for the presence or absence of PARP-1 in the nucleolus.
We found a significant decrease of PARP-1 staining in the nucleolar compartment of hippocampal pyramidal cells in MCI compared with Control and AD.
When the four CA (CA1-4) regions were considered separately, only the CA1 region showed significant differences in nucleolar PARP-1 with Control > AD > MCI cases.
Categorization of nucleolar PARP-1 into “distinct” and “diffuse” groups suggest that most of the changes occur within the distinct group.
In addition, measurements of the nucleolar diameter of nucleolar PARP-1 positive cells in CA2 and CA4 showed Control > MCI.
Thus, MCI cases had a lower percentage of PARP-1 nucleolar positive cells in CA1 and smaller nucleolar diameters in CA2 and CA4, compared to Control.
Our data suggest that disruption of nucleolar form and function is an early and important step in the progression of cognitive impairment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Regier, Matthew& Liang, Jiancong& Choi, Alexander& Verma, Kavita& Libien, Jenny& Hernández, A. Iván. 2019. Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment. Neural Plasticity،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1201431
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Regier, Matthew…[et al.]. Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment. Neural Plasticity No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1201431
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Regier, Matthew& Liang, Jiancong& Choi, Alexander& Verma, Kavita& Libien, Jenny& Hernández, A. Iván. Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1201431
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201431
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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