A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice
المؤلفون المشاركون
Han, Wei-Dong
Hao, Haojie
Liu, Jiejie
Tong, Chuan
Ti, Dongdong
Li, Meirong
Dong, Liang
Hou, Qian
Zheng, Jingxi
Liu, Gang
Fu, Xiaobing
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-27
دولة النشر
مصر
عدد الصفحات
13
الملخص EN
Mesenchymal stem cells (MSCs) can affect the microenvironment of a wound and thereby accelerate wound healing.
Wnt proteins act as key mediators of skin development and participate in the formation of skin appendages such as hair.
The mechanisms of action of MSCs and Wnt proteins on skin wounds are largely unknown.
Here, we prepared a Wnt7a-containing conditioned medium (Wnt-CM) from the supernatant of cultured human umbilical cord-MSCs (UC-MSCs) overexpressing Wnt7a in order to examine the effects of this CM on cutaneous healing.
Our results revealed that Wnt-CM can accelerate wound closure and induce regeneration of hair follicles.
Meanwhile, Wnt-CM enhanced expression of extracellular matrix (ECM) components and cell migration of fibroblasts but inhibited the migratory ability and expression of K6 and K16 in keratinocytes by enhancing expression of c-Myc.
However, we found that the CM of fibroblasts treated with Wnt-CM (HFWnt-CM-CM) can also promote wound repair and keratinocyte migration; but there was no increase in the number of hair follicles of regeneration.
These data indicate that Wnt7a and UC-MSCs have synergistic effects: they can accelerate wound repair and induce hair regeneration via cellular communication in the wound microenvironment.
Thus, this study opens up new avenues of research on the mechanisms underlying wound repair.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dong, Liang& Hao, Haojie& Liu, Jiejie& Ti, Dongdong& Tong, Chuan& Hou, Qian…[et al.]. 2017. A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice. Stem Cells International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1201437
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dong, Liang…[et al.]. A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice. Stem Cells International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1201437
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dong, Liang& Hao, Haojie& Liu, Jiejie& Ti, Dongdong& Tong, Chuan& Hou, Qian…[et al.]. A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1201437
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201437
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر