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Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study
المؤلفون المشاركون
Jiang, Wenyan
Lei, Yiwu
Wei, Jing
Yang, Lu
Wei, Shubao
Yin, Qiong
Luo, Shuguang
Guo, Wenbin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Cervical dystonia (CD) is a neurological movement disorder characterized by involuntary head and neck movements and postures.
Reports on microstructural and functional abnormalities in multiple brain regions not limited to the basal ganglia have been increasing in patients with CD.
However, the neural bases of CD are unclear.
This study is aimed at identifying cerebral functional abnormalities in CD by using resting-state functional magnetic resonance imaging (rs-fMRI).
Methods.
Using rs-fMRI data, voxel-mirrored homotopic connectivity (VMHC) and degree centrality were used to compare the alterations of the rs-functional connectivity (FC) between 19 patients with CD and 21 healthy controls.
Regions showing abnormal FCs from two measurements were the regions of interest for correlation analyses.
Results.
Compared with healthy controls, patients with CD exhibited significantly decreased VMHC in the supplementary motor area (SMA), precuneus (PCu)/postcentral gyrus, and superior medial prefrontal cortex (MPFC).
Significantly increased degree centrality in the right PCu and decreased degree centrality in the right lentiform nucleus and left ventral MPFC were observed in the patient group compared with the control group.
Further correlation analyses showed that the VMHC values in the SMA were negatively correlated with dystonia severity.
Conclusion.
Local abnormalities and interhemispheric interaction deficits in the sensorimotor network (SMA, postcentral gyrus, and PCu), default mode network (MPFC and PCu), and basal ganglia may be the key characteristics in the pathogenesis mechanism of CD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Wenyan& Lei, Yiwu& Wei, Jing& Yang, Lu& Wei, Shubao& Yin, Qiong…[et al.]. 2019. Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study. Neural Plasticity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1201596
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Wenyan…[et al.]. Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study. Neural Plasticity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1201596
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Wenyan& Lei, Yiwu& Wei, Jing& Yang, Lu& Wei, Shubao& Yin, Qiong…[et al.]. Alterations of Interhemispheric Functional Connectivity and Degree Centrality in Cervical Dystonia: A Resting-State fMRI Study. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1201596
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201596
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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