Sex Differences of Human Cardiac Progenitor Cells in the Biological Response to TNF-α Treatment
المؤلفون المشاركون
De Falco, Elena
Malorni, Walter
Chimenti, Isotta
Angelini, Francesco
Frati, G.
Cavarretta, Elena
La Russa, Raffaele
Pagano, Francesca
Ascione, Barbara
Vona, Rosa
Gambardella, Lucrezia
Straface, Elisabetta
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-17
دولة النشر
مصر
عدد الصفحات
9
الملخص EN
Adult cardiac progenitor cells (CPCs), isolated as cardiosphere-derived cells (CDCs), represent promising candidates for cardiac regenerative therapy.
CDCs can be expanded in vitro manyfolds without losing their differentiation potential, reaching numbers that are appropriate for clinical applications.
Since mechanisms of successful CDC survival and engraftment in the damaged myocardium are still critical and unresolved issues, we aimed at deciphering possible key factors capable of bolstering CDC function.
In particular, the response and the phenotype of CDCs exposed to low concentrations of the multifunctional cytokine tumor necrosis factor α (TNF-α), known to be capable of activating cell survival pathways, have been investigated.
Furthermore, differential biological responses of CDCs from male and female donors, in terms of cell cycle progression and cell spreading, have also been assessed.
The results obtained indicate that (i) the intracellular signaling activated in our experimental conditions is most likely due to the prosurvival and proliferative signaling of TNF-α receptor 2 and that (ii) cells from female patients appear more responsive to TNF-α treatment in terms of cell cycle progression and migration ability.
In conclusion, the present report highlights the hypothesis that TNF-stimulated CDCs isolated from females may represent a promising candidate for cardiac regenerative therapy applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Straface, Elisabetta& Gambardella, Lucrezia& Pagano, Francesca& Angelini, Francesco& Ascione, Barbara& Vona, Rosa…[et al.]. 2017. Sex Differences of Human Cardiac Progenitor Cells in the Biological Response to TNF-α Treatment. Stem Cells International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1201658
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Straface, Elisabetta…[et al.]. Sex Differences of Human Cardiac Progenitor Cells in the Biological Response to TNF-α Treatment. Stem Cells International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1201658
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Straface, Elisabetta& Gambardella, Lucrezia& Pagano, Francesca& Angelini, Francesco& Ascione, Barbara& Vona, Rosa…[et al.]. Sex Differences of Human Cardiac Progenitor Cells in the Biological Response to TNF-α Treatment. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1201658
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201658
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر