MicroRNA-219 Inhibits Proliferation and Induces Differentiation of Oligodendrocyte Precursor Cells after Contusion Spinal Cord Injury in Rats
المؤلفون المشاركون
Li, Fang
Zhou, Mou-Wang
Liu, Nan
Yang, Yan-Yan
Xing, Hua-Yi
Lu, Yao
Liu, Xiao-Xie
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-18
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
MicroRNA-219 (miR-219) regulates the proliferation and differentiation of oligodendrocyte precursor cells (OPCs) during central nervous system (CNS) development.
OPCs only differentiate into oligodendrocytes (OLs) in the healthy CNS, but can generate astrocytes (As) after injury.
We hypothesized that miR-219 may modulate OPC proliferation and differentiation in a cervical C5 contusion spinal cord injury (SCI) model.
After injury, we observed a decrease in the miR-219 level and quantity of OLs and an increase in the number of OPCs and As.
Silencing of miR-219 by its antagomir in vivo produced similar results, but of greater magnitude.
Overexpression of miR-219 by its agomir in vivo increased the number of OLs and suppressed generation of OPCs and As.
Luxol fast blue staining confirmed that SCI caused demyelination and that the extent of demyelination was attenuated by miR-219 overexpression, but aggravated by miR-219 reduction.
Monocarboxylate transporter 1 (MCT-1) may be implicated in the regulation of OPC proliferation and differentiation mediated by miR-219 following contusion SCI.
Collectively, our data suggest that miR-219 may mediate SCI-induced OPC proliferation and differentiation, and MCT-1 may participate in this process as a target of miR-219.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Fang& Zhou, Mou-Wang& Liu, Nan& Yang, Yan-Yan& Xing, Hua-Yi& Lu, Yao…[et al.]. 2019. MicroRNA-219 Inhibits Proliferation and Induces Differentiation of Oligodendrocyte Precursor Cells after Contusion Spinal Cord Injury in Rats. Neural Plasticity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1201689
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Fang…[et al.]. MicroRNA-219 Inhibits Proliferation and Induces Differentiation of Oligodendrocyte Precursor Cells after Contusion Spinal Cord Injury in Rats. Neural Plasticity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1201689
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Fang& Zhou, Mou-Wang& Liu, Nan& Yang, Yan-Yan& Xing, Hua-Yi& Lu, Yao…[et al.]. MicroRNA-219 Inhibits Proliferation and Induces Differentiation of Oligodendrocyte Precursor Cells after Contusion Spinal Cord Injury in Rats. Neural Plasticity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1201689
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201689
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر