Inhibition of Lysyl Oxidases Impairs Migration and Angiogenic Properties of Tumor-Associated Pericytes
المؤلفون المشاركون
Keith Okamoto, Oswaldo
Ribeiro, Aline Lopes
Kaid, Carolini
Silva, Patrícia B. G.
Cortez, Beatriz A.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-03
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
Pericytes are important cellular components of the tumor microenviroment with established roles in angiogenesis and metastasis.
These two cancer hallmarks are modulated by enzymes of the LOX family, but thus far, information about LOX relevance in tumor-associated pericytes is lacking.
Here, we performed a comparative characterization of normal and tumoral pericytes and report for the first time the modulatory effects of LOX enzymes on activated pericyte properties.
Tumoral pericytes isolated from childhood ependymoma and neuroblastoma specimens displayed angiogenic properties in vitro and expressed typical markers, including CD146, NG2, and PDGFRβ.
Expression of all LOX family members could be detected in both normal and tumor-associated pericytes.
In most pericyte samples, LOXL3 was the family member displaying the highest transcript levels.
Inhibition of LOX/LOXL activity with the inhibitor β-aminopropionitrile (βAPN) significantly reduced migration of pericytes, while proliferation rates were kept unaltered.
Formation of tube-like structures in vitro by pericytes was also significantly impaired upon inhibition of LOX/LOXL activity with βAPN, which induced more prominent effects in tumor-associated pericytes.
These findings reveal a novel involvement of the LOX family of enzymes in migration and angiogenic properties of pericytes, with implications in tumor development and in therapeutic targeting tumor microenvironment constituents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ribeiro, Aline Lopes& Kaid, Carolini& Silva, Patrícia B. G.& Cortez, Beatriz A.& Keith Okamoto, Oswaldo. 2017. Inhibition of Lysyl Oxidases Impairs Migration and Angiogenic Properties of Tumor-Associated Pericytes. Stem Cells International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1201698
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ribeiro, Aline Lopes…[et al.]. Inhibition of Lysyl Oxidases Impairs Migration and Angiogenic Properties of Tumor-Associated Pericytes. Stem Cells International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1201698
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ribeiro, Aline Lopes& Kaid, Carolini& Silva, Patrícia B. G.& Cortez, Beatriz A.& Keith Okamoto, Oswaldo. Inhibition of Lysyl Oxidases Impairs Migration and Angiogenic Properties of Tumor-Associated Pericytes. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1201698
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201698
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر