The Impact of Cerebral Amyloid Angiopathy in Various Neurodegenerative Dementia Syndromes: A Neuropathological Study

الملخص EN

Purpose.

The Boston criteria for cerebral amyloid angiopathy (CAA) have to be confirmed by postmortem examination.

The present study investigates the incidence and the cerebrovascular impact of the severity of CAA in various neurodegenerative dementia diseases.

Material and Methods.

208 patients underwent an autopsy.

They consisted of 92 brains with Alzheimer’s disease (AD), 46 with frontotemporal lobar degeneration (FTLD), 24 with progressive supranuclear palsy (PSP), 21 with Lewy body dementia (LBD), 5 with corticobasal degeneration (CBD), and 20 controls.

In addition to the macroscopic examination, a whole coronal section of a cerebral hemisphere, at the level of the mamillary body, was taken for semiquantitative microscopic evaluation of the small cerebrovascular lesions.

Results.

CAA is present in 2/3% of the AD brains of which half of them have a severe form, grade 3.

Only the latter displays more cerebrovascular lesions.

CAA is present in 45% of the LBD brains.

Cortical microinfarcts are only more frequent in the CAA grade 3 group.

In LBD additional AD pathology is present in 41% of the CAA grade 0, 83% in grade 1-2, and 100% in grade 3.

In PSP only 21% had CAA grade 1-2.

In FTLD, CBD, and normal controls no CAA pathology is observed.

Conclusions.

The present study shows that CAA is most frequently associated to AD but that only the severe form displays more cerebrovascular lesions.

LBD is the second most frequent disease associated to CAA with a clear correlation between the incidence of the associated AD features and the increasing severity of the CAA.

In PSP only 21% display mild CAA features.

PSP, tau-FTLD, and CBD are part of the Pick complex diseases, who are known to have a favourable vascular profile which can explain their low incidence of cerebrovascular lesions, in contrast to AD and LBD brains.