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Challenges in Managing Patients with Hereditary Cancer at Gynecological Services
المؤلفون المشاركون
Sawai, Hideaki
Wakimoto, Yu
Shibahara, Hiroaki
Ueda, Mako
Tsubamoto, Hiroshi
Kashima-Morii, Mina
Torii, Yoshitaka
Kamihigashi, Mariko
Nakagomi, Nami
Hashimoto-Tamaoki, Tomoko
المصدر
Obstetrics and Gynecology International
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aim.
To reveal current problems and challenges faced by our gynecologic services department in managing patients with hereditary cancers.
Methods.
We collected clinical data of patients with hereditary cancers, identified via genetic testing (or clinically diagnosed in cases of Cowden syndrome or Peutz–Jeghers syndrome), and treated in our gynecological department from 2012 to 2018.
Results.
Fifteen patients had hereditary breast and ovarian cancer (HBOC), 6 had Lynch syndrome, 2 had Cowden syndrome, and 2 had Peutz–Jeghers syndrome.
Five patients diagnosed with HBOC were younger than 40 years at diagnosis.
Risk-reducing salpingo-oophorectomy (RRSO) was performed on 1 patient with a BRCA1 mutation at age 38 years.
Seven patients overall underwent RRSO, and none had malignancies on pathological examinations.
Peritoneal washing cytology (PWC) was suspicious for malignancy in one patient; however, subsequent PWC at 6 months after RRSO was negative.
A patient with endometrial cancer and Lynch syndrome and a patient with atypical endometrial hyperplasia (AEH) and Cowden syndrome strongly desired fertility preservation.
They achieved remission after medroxyprogesterone acetate treatment and multiple dilations and curettages, respectively.
One patient with Lynch syndrome developed AEH after 11 years of surveillance.
Laparotomy revealed adjacent low-grade and high-grade serous ovarian cancer with positive ascites cytology.
She had no recurrence during 7-year follow-up after laparotomy.
Conclusion.
Managing patients with hereditary cancer, positive or false-positive ascites cytology discovered during RRSO, and desired preservation of fertility is highly challenging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ueda, Mako& Tsubamoto, Hiroshi& Kashima-Morii, Mina& Torii, Yoshitaka& Kamihigashi, Mariko& Wakimoto, Yu…[et al.]. 2019. Challenges in Managing Patients with Hereditary Cancer at Gynecological Services. Obstetrics and Gynecology International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1201824
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ueda, Mako…[et al.]. Challenges in Managing Patients with Hereditary Cancer at Gynecological Services. Obstetrics and Gynecology International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1201824
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ueda, Mako& Tsubamoto, Hiroshi& Kashima-Morii, Mina& Torii, Yoshitaka& Kamihigashi, Mariko& Wakimoto, Yu…[et al.]. Challenges in Managing Patients with Hereditary Cancer at Gynecological Services. Obstetrics and Gynecology International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1201824
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201824
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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