Maternal Sevoflurane Exposure Causes Abnormal Development of Fetal Prefrontal Cortex and Induces Cognitive Dysfunction in Offspring
المؤلفون المشاركون
Xue, ZhangGang
Song, Ruixue
Ling, Xiaomin
Peng, Mengyuan
Cang, Jing
Fang, Fang
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-25
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Maternal sevoflurane exposure during pregnancy is associated with increased risk for behavioral deficits in offspring.
Several studies indicated that neurogenesis abnormality may be responsible for the sevoflurane-induced neurotoxicity, but the concrete impact of sevoflurane on fetal brain development remains poorly understood.
We aimed to investigate whether maternal sevoflurane exposure caused learning and memory impairment in offspring through inducing abnormal development of the fetal prefrontal cortex (PFC).
Pregnant mice at gestational day 15.5 received 2.5% sevoflurane for 6 h.
Learning function of the offspring was evaluated with the Morris water maze test at postnatal day 30.
Brain tissues of fetal mice were subjected to immunofluorescence staining to assess differentiation, proliferation, and cell cycle dynamics of the fetal PFC.
We found that maternal sevoflurane anesthesia impaired learning ability in offspring through inhibiting deep-layer immature neuron output and neuronal progenitor replication.
With the assessment of cell cycle dynamics, we established that these effects were mediated through cell cycle arrest in neural progenitors.
Our research has provided insights into the cell cycle-related mechanisms by which maternal sevoflurane exposure can induce neurodevelopmental abnormalities and learning dysfunction and appeals people to consider the neurotoxicity of anesthetics when considering the benefits and risks of nonobstetric surgical procedures.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Ruixue& Ling, Xiaomin& Peng, Mengyuan& Xue, ZhangGang& Cang, Jing& Fang, Fang. 2017. Maternal Sevoflurane Exposure Causes Abnormal Development of Fetal Prefrontal Cortex and Induces Cognitive Dysfunction in Offspring. Stem Cells International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201937
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Ruixue…[et al.]. Maternal Sevoflurane Exposure Causes Abnormal Development of Fetal Prefrontal Cortex and Induces Cognitive Dysfunction in Offspring. Stem Cells International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1201937
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Ruixue& Ling, Xiaomin& Peng, Mengyuan& Xue, ZhangGang& Cang, Jing& Fang, Fang. Maternal Sevoflurane Exposure Causes Abnormal Development of Fetal Prefrontal Cortex and Induces Cognitive Dysfunction in Offspring. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1201937
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201937
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر