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The Impact of CRISPRCas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches
المؤلفون المشاركون
Motta, Benedetta M.
Pramstaller, Peter P.
Hicks, Andrew A.
Rossini, Alessandra
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-25
دولة النشر
مصر
عدد الصفحات
13
الملخص EN
Genome-editing technology has emerged as a powerful method that enables the generation of genetically modified cells and organisms necessary to elucidate gene function and mechanisms of human diseases.
The clustered regularly interspaced short palindromic repeats- (CRISPR-) associated 9 (Cas9) system has rapidly become one of the most popular approaches for genome editing in basic biomedical research over recent years because of its simplicity and adaptability.
CRISPR/Cas9 genome editing has been used to correct DNA mutations ranging from a single base pair to large deletions in both in vitro and in vivo model systems.
CRISPR/Cas9 has been used to increase the understanding of many aspects of cardiovascular disorders, including lipid metabolism, electrophysiology and genetic inheritance.
The CRISPR/Cas9 technology has been proven to be effective in creating gene knockout (KO) or knockin in human cells and is particularly useful for editing induced pluripotent stem cells (iPSCs).
Despite these progresses, some biological, technical, and ethical issues are limiting the therapeutic potential of genome editing in cardiovascular diseases.
This review will focus on various applications of CRISPR/Cas9 genome editing in the cardiovascular field, for both disease research and the prospect of in vivo genome-editing therapies in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Motta, Benedetta M.& Pramstaller, Peter P.& Hicks, Andrew A.& Rossini, Alessandra. 2017. The Impact of CRISPRCas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches. Stem Cells International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1202319
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Motta, Benedetta M.…[et al.]. The Impact of CRISPRCas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches. Stem Cells International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1202319
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Motta, Benedetta M.& Pramstaller, Peter P.& Hicks, Andrew A.& Rossini, Alessandra. The Impact of CRISPRCas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1202319
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202319
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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