The Healing of Oxidative Injuries with Trehalose in UVB-Irradiated Rabbit Corneas
المؤلفون المشاركون
Holan, Vladimir
Cejka, Cestmir
Kossl, Jan
Hermankova, Barbora
Kubinova, Sarka
Olmiere, Céline
Cejkova, Jitka
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Our previous research revealed that trehalose, a nonreducing disaccharide of glucose and an important stress responsive factor, proved to have anti-inflammatory, antiapoptotic, and particularly antioxidant properties in UVB-irradiated corneas.
Trehalose reduced oxidative stress in corneas induced by UVB irradiation, by means of a decrease in the antioxidant/prooxidant imbalance in the corneal epithelium.
In this study, we demonstrate that trehalose of 3% or 6% concentration in eye drops directly decreases oxidative stress in UVB-irradiated corneas, by removing the excessive amount of reactive oxygen species (ROS).
Trehalose drops applied on corneas during UVB irradiation once daily for four days resulted in a reduction or even absence of the oxidative stress, DNA damage, and peroxynitrite formation (detected by nitrotyrosine residues), seen in buffer-treated corneas.
Furthermore, trehalose treatment applied curatively after repeated irradiation for the subsequent fourteen days led to the renewal of corneal transparency and significant suppression or even absence of neovascularization.
This was in contrast to buffer-treated irradiated corneas, where the intracorneal inflammation was developed and the untransparent corneas were vascularized.
In conclusion, the treatment of UVB-irradiated corneas with trehalose eye drops removed the excessive amount of ROS in the corneal epithelium, leading to the suppression of oxidative stress and favorable corneal healing.
The 6% trehalose showed a higher intensive antioxidant effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cejka, Cestmir& Kossl, Jan& Hermankova, Barbora& Holan, Vladimir& Kubinova, Sarka& Olmiere, Céline…[et al.]. 2019. The Healing of Oxidative Injuries with Trehalose in UVB-Irradiated Rabbit Corneas. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1202390
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cejka, Cestmir…[et al.]. The Healing of Oxidative Injuries with Trehalose in UVB-Irradiated Rabbit Corneas. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1202390
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cejka, Cestmir& Kossl, Jan& Hermankova, Barbora& Holan, Vladimir& Kubinova, Sarka& Olmiere, Céline…[et al.]. The Healing of Oxidative Injuries with Trehalose in UVB-Irradiated Rabbit Corneas. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1202390
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202390
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر