Pretreatment with Cholecalciferol Alleviates Renal Cellular Stress Response during IschemiaReperfusion-Induced Acute Kidney Injury
المؤلفون المشاركون
Li, Jun
Xu, Shen
Zhu, Jin-Bo
Song, Jin
Luo, Biao
Song, Ya-Ping
Zhang, Zhi-Hui
Chen, Yuan-Hua
Zhang, Zhi-Qiang
Xie, Dong-Dong
Yu, De-Xin
Xu, De-Xiang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-25
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Cellular stress is involved in ischemia/reperfusion- (I/R-) induced acute kidney injury (AKI).
This study is aimed at investigating the effects of pretreatment with cholecalciferol on renal oxidative stress and endoplasmic reticulum (ER) stress during I/R-induced AKI.
Methods.
I/R-induced AKI was established by cross-clamping renal pedicles for 90 minutes and then reperfusion.
In the Chol+I/R group, mice were orally administered with three doses of cholecalciferol (25 μg/kg) at 1, 24, and 48 h before ischemia.
Renal cellular stress and kidney injury were measured at different time points after reperfusion.
Results.
I/R-induced AKI was alleviated in mice pretreated with cholecalciferol.
In addition, I/R-induced renal cell apoptosis, as determined by TUNEL, was suppressed by cholecalciferol.
Additional experiment showed that I/R-induced upregulation of renal GRP78 and CHOP was inhibited by cholecalciferol.
I/R-induced renal IRE1α and eIF2α phosphorylation was attenuated by cholecalciferol.
Moreover, I/R-induced renal GSH depletion, lipid peroxidation, and protein nitration were blocked in mice pretreated with cholecalciferol.
I/R-induced upregulation of renal NADPH oxidases, such as p47phox, gp91phox, and nox4, was inhibited by cholecalciferol.
I/R-induced upregulation of heme oxygenase- (HO-) 1, gshpx and gshrd, was attenuated in mice pretreated with cholecalciferol.
Conclusions.
Pretreatment with cholecalciferol protects against I/R-induced AKI partially through suppressing renal cellular stress response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jun& Xu, Shen& Zhu, Jin-Bo& Song, Jin& Luo, Biao& Song, Ya-Ping…[et al.]. 2019. Pretreatment with Cholecalciferol Alleviates Renal Cellular Stress Response during IschemiaReperfusion-Induced Acute Kidney Injury. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1202418
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jun…[et al.]. Pretreatment with Cholecalciferol Alleviates Renal Cellular Stress Response during IschemiaReperfusion-Induced Acute Kidney Injury. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1202418
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jun& Xu, Shen& Zhu, Jin-Bo& Song, Jin& Luo, Biao& Song, Ya-Ping…[et al.]. Pretreatment with Cholecalciferol Alleviates Renal Cellular Stress Response during IschemiaReperfusion-Induced Acute Kidney Injury. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1202418
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202418
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر