Delayed Pulmonary Apoptosis of Diet-Induced Obesity Mice following Escherichia coli Infection through the Mitochondrial Apoptotic Pathway
المؤلفون المشاركون
Fang, Jing
Ou, Yangping
Geng, Yi
Cui, Hengmin
Wang, Fengyuan
Yang, Zhuangzhi
Chen, Kejie
Shu, Gang
Zhou, Yi
Zuo, Z. C.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-22
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Escherichia coli (E.
coli) is one of pathogens causing nosocomial pneumonia and could induce pulmonary excessive apoptosis.
Although much has been learned about metabolic diseases induced by obesity, the information linking bacterial pneumonia to obesity is limited.
Accordingly, we investigated the apoptosis of normal (lean) and diet-induced obesity (DIO, fed a high-fat diet) mice after nasal instillation with E.
coli.
Lung tissues were obtained at 0 (preinfection), 12, 24, and 72 h after infection, and acute pulmonary inflammation was observed at 12 h.
Elevated cell apoptosis and percentage of pulmonary cells depolarized with collapse of the mitochondrial transmembrane potential (Δψm) occurred in response to bacterial infection.
The relative mRNA and protein expressions of Bax, caspase-3, and caspase-9 increased, but Bcl-2 decreased in the lung.
Interestingly, the apoptotic percentage and most of apoptosis-associated factors mentioned above peaked at 12 or 24 h in the lean-E.
coli group, while at 24 or 72 h in the DIO-E.
coli group.
Taken together, these findings indicated that the E.
coli pneumonia caused excessive pulmonary apoptosis through the mitochondria-mediated pathway, and the apoptosis was delayed in the DIO mice with E.
coli pneumonia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Fengyuan& Zuo, Z. C.& Yang, Zhuangzhi& Chen, Kejie& Fang, Jing& Cui, Hengmin…[et al.]. 2019. Delayed Pulmonary Apoptosis of Diet-Induced Obesity Mice following Escherichia coli Infection through the Mitochondrial Apoptotic Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1202444
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Fengyuan…[et al.]. Delayed Pulmonary Apoptosis of Diet-Induced Obesity Mice following Escherichia coli Infection through the Mitochondrial Apoptotic Pathway. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1202444
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Fengyuan& Zuo, Z. C.& Yang, Zhuangzhi& Chen, Kejie& Fang, Jing& Cui, Hengmin…[et al.]. Delayed Pulmonary Apoptosis of Diet-Induced Obesity Mice following Escherichia coli Infection through the Mitochondrial Apoptotic Pathway. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1202444
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202444
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر