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Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models
المؤلفون المشاركون
Falabella, Paulo
Thomas, Biju B.
Hinton, David R.
Lin, Tai-Chi
Zhu, Danhong
Clegg, Dennis O.
Humayun, Mark S.
Seiler, M. J.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-27
دولة النشر
مصر
عدد الصفحات
19
الملخص EN
Dysfunction and death of retinal pigment epithelium (RPE) and or photoreceptors can lead to irreversible vision loss.
The eye represents an ideal microenvironment for stem cell-based therapy.
It is considered an “immune privileged” site, and the number of cells needed for therapy is relatively low for the area of focused vision (macula).
Further, surgical placement of stem cell-derived grafts (RPE, retinal progenitors, and photoreceptor precursors) into the vitreous cavity or subretinal space has been well established.
For preclinical tests, assessments of stem cell-derived graft survival and functionality are conducted in animal models by various noninvasive approaches and imaging modalities.
In vivo experiments conducted in animal models based on replacing photoreceptors and/or RPE cells have shown survival and functionality of the transplanted cells, rescue of the host retina, and improvement of visual function.
Based on the positive results obtained from these animal experiments, human clinical trials are being initiated.
Despite such progress in stem cell research, ethical, regulatory, safety, and technical difficulties still remain a challenge for the transformation of this technique into a standard clinical approach.
In this review, the current status of preclinical safety and efficacy studies for retinal cell replacement therapies conducted in animal models will be discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Tai-Chi& Seiler, M. J.& Zhu, Danhong& Falabella, Paulo& Hinton, David R.& Clegg, Dennis O.…[et al.]. 2017. Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models. Stem Cells International،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1202484
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Tai-Chi…[et al.]. Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models. Stem Cells International No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1202484
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Tai-Chi& Seiler, M. J.& Zhu, Danhong& Falabella, Paulo& Hinton, David R.& Clegg, Dennis O.…[et al.]. Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1202484
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202484
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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