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Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View
المؤلفون المشاركون
Cascella, Roberta
Lloret, Ana
Cenini, Giovanna
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-09
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Age is the main risk factor for a number of human diseases, including neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, which increasing numbers of elderly individuals suffer.
These pathological conditions are characterized by progressive loss of neuron cells, compromised motor or cognitive functions, and accumulation of abnormally aggregated proteins.
Mitochondrial dysfunction is one of the main features of the aging process, particularly in organs requiring a high-energy source such as the heart, muscles, brain, or liver.
Neurons rely almost exclusively on the mitochondria, which produce the energy required for most of the cellular processes, including synaptic plasticity and neurotransmitter synthesis.
The brain is particularly vulnerable to oxidative stress and damage, because of its high oxygen consumption, low antioxidant defenses, and high content of polyunsaturated fats very prone to be oxidized.
Thus, it is not surprising the importance of protecting systems, including antioxidant defenses, to maintain neuronal integrity and survival.
Here, we review the role of mitochondrial oxidative stress in the aging process, with a specific focus on neurodegenerative diseases.
Understanding the molecular mechanisms involving mitochondria and oxidative stress in the aging and neurodegeneration may help to identify new strategies for improving the health and extending lifespan.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cenini, Giovanna& Lloret, Ana& Cascella, Roberta. 2019. Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1202518
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cenini, Giovanna…[et al.]. Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-18.
https://search.emarefa.net/detail/BIM-1202518
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cenini, Giovanna& Lloret, Ana& Cascella, Roberta. Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-18.
https://search.emarefa.net/detail/BIM-1202518
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202518
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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