Resistin in Human Seminal Plasma: Relationship with Lipid Peroxidation, CAT Activity, GSHGSSG Ratio, and Semen Parameters
المؤلفون المشاركون
Moretti, E.
Noto, Daria
Micheli, Lucia
Fiaschi, Anna Ida
Menchiari, Andrea
Cerretani, Daniela
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Resistin is an adipokine involved in inflammation and able to induce the expression of other proinflammatory cytokines.
It is known that, in human semen, resistin is correlated with inflammatory cytokines and sperm quality.
The aim of this prospective study was to explore the potential relationship between resistin, lipid peroxidation (LPO), catalase (CAT) activity, and reduced and oxidized glutathione (GSH/GSSG) ratio in semen samples of infertile patients with leukocytospermia (no.
19), infertile patients with varicocele (no.
17), and fertile men (no.
17).
Semen analysis was performed following the WHO guidelines, and sperm apoptosis and necrosis were evaluated with annexin V/propidium iodide assay.
Seminal plasma samples were used to determine resistin levels by an immunological method, MDA concentration by a HPLC analysis with UV detection, GSH/GSSG ratio by an enzymatic method, CAT activity by a spectrophotometric method.
The results showed that, in both groups of infertile patients, semen parameters were significantly reduced (P<0.001) and sperm apoptosis and necrosis percentages were increased.
Resistin levels were significantly higher in leukocytospermia and varicocele groups (P<0.001 and P<0.01, respectively) as well as MDA concentration (P<0.001) compared to controls.
The MDA level was also significantly increased in the leukocytospermia group versus the varicocele group (P<0.05).
The GSH/GSSG ratio was higher in fertile controls than the leukocytospermia group (P<0.05) and the varicocele group (P<0.001) and in the leukocytospermia group versus the varicocele group (P<0.05).
Both the leukocytospermia and varicocele groups showed increased values of CAT activities (P<0.001) than controls.
Briefly, the correlation between variables, calculated in the whole patient population, showed that resistin levels positively correlated with MDA levels, CAT activity, sperm apoptosis, and necrosis and negatively with sperm parameters and GSH/GSSG ratio.
These results support an active role of resistin in an inflammatory process causing LPO, increase of CAT activity, and decrease of GSH/GSSG ratio in seminal plasma of infertile men vs.
fertile controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moretti, E.& Micheli, Lucia& Noto, Daria& Fiaschi, Anna Ida& Menchiari, Andrea& Cerretani, Daniela. 2019. Resistin in Human Seminal Plasma: Relationship with Lipid Peroxidation, CAT Activity, GSHGSSG Ratio, and Semen Parameters. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1202541
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moretti, E.…[et al.]. Resistin in Human Seminal Plasma: Relationship with Lipid Peroxidation, CAT Activity, GSHGSSG Ratio, and Semen Parameters. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1202541
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moretti, E.& Micheli, Lucia& Noto, Daria& Fiaschi, Anna Ida& Menchiari, Andrea& Cerretani, Daniela. Resistin in Human Seminal Plasma: Relationship with Lipid Peroxidation, CAT Activity, GSHGSSG Ratio, and Semen Parameters. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1202541
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202541
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر