Teriflunomide Safety and Efficacy in Advanced Progressive Multiple Sclerosis
المؤلفون المشاركون
Healy, Brian C.
Moreira Ferreira, Vanessa F.
Caefer, Danielle
Erlich-Malona, Natalie
Chitnis, Tanuja
Stankiewicz, James M.
المصدر
Multiple Sclerosis International
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
To explore the safety and efficacy profile of teriflunomide in progressive multiple sclerosis.
Methods.
We conducted a single-center retrospective observational analysis of a progressive multiple sclerosis population, assessing safety and efficacy in patients treated at least one year with teriflunomide or glatiramer acetate.
Sustained progression of expanded disability status scale and sustained worsening of timed 25-foot walk were compared using a Cox proportional hazards model.
Results.
Teriflunomide group (n=29) mean characteristics: age=58 years (SD±7.6), disease duration=16.7 years (SD±9.5), expanded disability status score=5.9 (SD±1.3), and follow−up=32.4 months (SD±13.6).
Glatiramer acetate group (n=30) mean characteristics: age=52.4 years (SD±11.3), disease duration=15.1 years (SD±10.4), expanded disability status score=5.7 (SD±1.6), and follow−up=46.9 months (SD±43.9).
Both treatments were well tolerated without serious side effects.
After adjustment for age, sex, and baseline expanded disability status score, sustained expanded disability status score progression did not differ between groups (hazard ratio=1.17; 95% confidence interval: 0.45, 3.08; p=0.75).
Sustained timed 25-foot walk worsening after adjustment also did not differ (hazard ratio=0.56; 95% confidence interval: 0.2, 1.53; p=0.26).
Conclusion.
In an advanced progressive multiple sclerosis population, no substantial differences in tolerability, safety, sustained EDSS progression, or sustained T25FW worsening over time were observed between glatiramer acetate and teriflunomide-treated groups.
The small sample precluded definitive determination.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moreira Ferreira, Vanessa F.& Caefer, Danielle& Erlich-Malona, Natalie& Healy, Brian C.& Chitnis, Tanuja& Stankiewicz, James M.. 2020. Teriflunomide Safety and Efficacy in Advanced Progressive Multiple Sclerosis. Multiple Sclerosis International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1202574
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moreira Ferreira, Vanessa F.…[et al.]. Teriflunomide Safety and Efficacy in Advanced Progressive Multiple Sclerosis. Multiple Sclerosis International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1202574
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moreira Ferreira, Vanessa F.& Caefer, Danielle& Erlich-Malona, Natalie& Healy, Brian C.& Chitnis, Tanuja& Stankiewicz, James M.. Teriflunomide Safety and Efficacy in Advanced Progressive Multiple Sclerosis. Multiple Sclerosis International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1202574
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202574
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر