Outcomes and Adverse Effects of Deep Brain Stimulation on the Ventral Intermediate Nucleus in Patients with Essential Tremor
المؤلفون المشاركون
Duan, Jian
Hua, Xing
Hong, Tao
Chen, Xiaosi
Zheng, Zijian
Lu, Guohui
Luo, Linfeng
Liu, Maolin
Zhang, Bohan
Fan, Houyou
Mo, Guoheng
Li, MeiHua
Zhou, Dongwei
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Objective.
This study was aimed at identifying the potential outcome predictors, comparing the efficacy in patients with different tremor characteristics, and summarizing the adverse effect rates (AERs) of deep brain stimulation on the ventral intermediate nucleus (VIM-DBS) for essential tremor (ET).
Methods.
An extensive search of articles published to date in 2019 was conducted, and two main aspects were analyzed.
Improvement was calculated as a percentage of change in any objective tremor rating scale (TRS) and analyzed by subgroup analyses of patients’ tremor characteristics, laterality, and stimulation parameters.
Furthermore, the AERs were analyzed as follows: the adverse effects (AEs) were classified as stimulation-related, surgical-related, or device-related effects.
A simple regression analysis was used to identify the potential prognostic factors, and a two-sample mean-comparison test was used to verify the statistical significance of the subgroup analyses.
Results.
Forty-six articles involving 1714 patients were included in the meta-analysis.
The pooled improvement in any objective TRS score was 61.3% (95% CI: 0.564-0.660) at the mean follow-up visit (20.0±17.3 months).
The midline and extremity symptoms showed consistent improvement (P=0.440), and the results of the comparison of postural and kinetic tremor were the same (P=0.219).
In addition, the improvement in rest tremor was similar to that in action tremor (OR=2.759, P=0.120).
In the simple regression analysis, the preoperative Fahn-Tolosa-Marin Tremor Rating Scale (FTM-TRS) scores and follow-up time were negatively correlated with the percentage change in any objective TRS score (P<0.05).
The most common adverse event was dysarthria (10.5%), which is a stimulation-related AE (23.6%), while the rates of the surgical-related and device-related AEs were 6.4% and 11.5%, respectively.
Conclusion.
VIM-DBS is an efficient and safe surgical method in ET, and the efficacy was not affected by the body distribution of tremor, age at surgery, and disease duration.
Lower preoperative FTM-TRS scores likely indicate greater improvement, and the effect of VIM-DBS declines over time.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Guohui& Luo, Linfeng& Liu, Maolin& Zheng, Zijian& Zhang, Bohan& Chen, Xiaosi…[et al.]. 2020. Outcomes and Adverse Effects of Deep Brain Stimulation on the Ventral Intermediate Nucleus in Patients with Essential Tremor. Neural Plasticity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1202648
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Guohui…[et al.]. Outcomes and Adverse Effects of Deep Brain Stimulation on the Ventral Intermediate Nucleus in Patients with Essential Tremor. Neural Plasticity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1202648
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Guohui& Luo, Linfeng& Liu, Maolin& Zheng, Zijian& Zhang, Bohan& Chen, Xiaosi…[et al.]. Outcomes and Adverse Effects of Deep Brain Stimulation on the Ventral Intermediate Nucleus in Patients with Essential Tremor. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1202648
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202648
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر