Serum BDNF Levels Are Reduced in Patients with Disorders of Consciousness and Are Not Modified by Verticalization with Robot-Assisted Lower-Limb Training
المؤلفون المشاركون
Bagnato, Sergio
Ribaudo, Francesco
Fiorilla, Teresa Valentina
Rubino, Francesca
D’Ippolito, Maria Enza
Andriolo, Maria
Galardi, Giuseppe
Boccagni, Cristina
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Little is known about plastic changes occurring in the brains of patients with severe disorders of consciousness (DOCs) caused by acute brain injuries at rest and during rehabilitative treatment.
Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in neurogenesis and synaptic plasticity whose production is powerfully modulated by physical exercise.
In this study, we compared serum BDNF levels in 18 patients with unresponsive wakefulness syndrome (UWS) and in a minimally conscious state (MCS) with those in 16 sex- and age-matched healthy controls.
In 12 patients, serum BDNF levels before and after verticalization with ErigoPro robot-assisted lower-limb training were compared.
Serum BDNF levels were significantly lower in patients (median, 1141 pg/ml; 25th and 75th percentiles, 1016 and 1704 pg/ml) than in controls (median, 2450 pg/ml; 25th and 75th percentiles, 2100 and 2875 pg/ml; p<0.001).
BDNF levels measured before and after verticalization with robot-assisted lower-limb training did not change (p=0.5).
Moreover, BDNF levels did not differ between patients with UWS and MCS (p=0.2), or between patients with traumatic and nontraumatic brain injuries (p=0.6).
BDNF level correlated positively with the time since brain injury (p=0.025).
In conclusion, serum BDNF levels are reduced in patients with UWS and MCS and cannot be improved by verticalization associated with passive lower-limb training.
Additional studies are needed to better understand the mechanisms underlying BDNF reduction in patients with DOCs and to determine the best rehabilitative strategies to promote restorative plastic changes in these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bagnato, Sergio& Galardi, Giuseppe& Ribaudo, Francesco& Boccagni, Cristina& Fiorilla, Teresa Valentina& Rubino, Francesca…[et al.]. 2020. Serum BDNF Levels Are Reduced in Patients with Disorders of Consciousness and Are Not Modified by Verticalization with Robot-Assisted Lower-Limb Training. Neural Plasticity،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1202703
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bagnato, Sergio…[et al.]. Serum BDNF Levels Are Reduced in Patients with Disorders of Consciousness and Are Not Modified by Verticalization with Robot-Assisted Lower-Limb Training. Neural Plasticity No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1202703
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bagnato, Sergio& Galardi, Giuseppe& Ribaudo, Francesco& Boccagni, Cristina& Fiorilla, Teresa Valentina& Rubino, Francesca…[et al.]. Serum BDNF Levels Are Reduced in Patients with Disorders of Consciousness and Are Not Modified by Verticalization with Robot-Assisted Lower-Limb Training. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1202703
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202703
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر