![](/images/graphics-bg.png)
Transcriptome Analysis and Emerging Driver Identification of CD8+ T Cells in Patients with Vitiligo
المؤلفون المشاركون
Xiao, Yangfan
Zeng, Zhuotong
Shi, Yaqian
Tang, Bingsi
Xiao, Rong
Deng, Qiancheng
Wei, Jingchao
Zou, Puyu
Zhan, Yi
Zhang, Huiming
Zeng, Qinghai
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-26
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Activated CD8+ T cells play important roles in the pathogenesis of vitiligo.
However, driving factors about the activation and migration of CD8+ T cells remain obscure.
In this study, we aim to identify differentially expressed genes (DEGs) and uncover potential factors that drive the disease in melanocyte-specific CD8+ T cells in vitiligo.
A total of 1147 DEGs were found through transcriptome sequencing in CD8+ T cells from lesional skin of vitiligo patients and normal controls.
Based on KEGG pathway enrichment analysis and PPI, 16 upregulated and 23 downregulated genes were identified.
Ultimately, 3 genes were figured out after RT-qPCR verification.
The mRNA and protein expression levels of PIK3CB, HIF-1α, and F2RL1 were all elevated in CD8+ T cells from peripheral blood in vitiligo.
HIF-1α and PIK3CB were significantly increased in lesional skin of vitiligo.
Two CpG sites of the HIF-1α promoter were hypomethylated in vitiligo CD8+ T cells.
In conclusion, HIF-1α, F2RL1, and PIK3CB may act as novel drivers for vitiligo, which are all closely associated with reactive oxygen species and possibly contribute to the activation and/or migration of melanocyte-specific CD8+ T cells in vitiligo.
In addition, we uncovered a potential role for DNA hypomethylation of HIF-1α in CD8+ T cells of vitiligo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deng, Qiancheng& Wei, Jingchao& Zou, Puyu& Xiao, Yangfan& Zeng, Zhuotong& Shi, Yaqian…[et al.]. 2019. Transcriptome Analysis and Emerging Driver Identification of CD8+ T Cells in Patients with Vitiligo. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1202721
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deng, Qiancheng…[et al.]. Transcriptome Analysis and Emerging Driver Identification of CD8+ T Cells in Patients with Vitiligo. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1202721
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deng, Qiancheng& Wei, Jingchao& Zou, Puyu& Xiao, Yangfan& Zeng, Zhuotong& Shi, Yaqian…[et al.]. Transcriptome Analysis and Emerging Driver Identification of CD8+ T Cells in Patients with Vitiligo. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1202721
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202721
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)