The Emerging Role of Estrogens in Thyroid Redox Homeostasis and Carcinogenesis
المؤلفون المشاركون
Fortunato, Rodrigo S.
Faria, Caroline C.
Peixoto, Milena S.
Carvalho, Denise P.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-09
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Reactive oxygen species (ROS) are the most critical class of free radicals or reactive metabolites produced by all living organisms.
ROS regulate several cellular functions through redox-dependent mechanisms, including proliferation, differentiation, hormone synthesis, and stress defense response.
However, ROS overproduction or lack of appropriate detoxification is harmful to cells and can be linked to the development of several diseases, such as cancer.
Oxidative damage in cellular components, especially in DNA, can promote the malignant transformation that has already been described in thyroid tissue.
In thyrocyte physiology, NADPH oxidase enzymes produce large amounts of ROS that are necessary for hormone biosynthesis and might contribute to the high spontaneous mutation rate found in this tissue.
Thyroid cancer is the most common endocrine malignancy, and its incidence is significantly higher in women than in men.
Several lines of evidence suggest the sex hormone estrogen as a risk factor for thyroid cancer development.
Estrogen in turn, besides being a potent growth factor for both normal and tumor thyroid cells, regulates different mechanisms of ROS generation.
Our group demonstrated that the thyroid gland of adult female rats exhibits higher hydrogen peroxide (H2O2) production and lower enzymatic antioxidant defense in comparison with male glands.
In this review, we discuss the possible involvement of thyroid redox homeostasis and estrogen in the development of thyroid carcinogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Faria, Caroline C.& Peixoto, Milena S.& Carvalho, Denise P.& Fortunato, Rodrigo S.. 2019. The Emerging Role of Estrogens in Thyroid Redox Homeostasis and Carcinogenesis. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1202731
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Faria, Caroline C.…[et al.]. The Emerging Role of Estrogens in Thyroid Redox Homeostasis and Carcinogenesis. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1202731
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Faria, Caroline C.& Peixoto, Milena S.& Carvalho, Denise P.& Fortunato, Rodrigo S.. The Emerging Role of Estrogens in Thyroid Redox Homeostasis and Carcinogenesis. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1202731
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202731
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر