Hsp70Bmi1-FoxO1-SOD Signaling Pathway Contributes to the Protective Effect of Sound Conditioning against Acute Acoustic Trauma in a Rat Model
المؤلفون المشاركون
Chen, Yuanyuan
Wu, Yongxiang
Qiu, Yang
Zhu, Guoxia
Tian, Keyong
Mi, Wenjuan
Liu, Xinqin
Jia, Jinwen
Luo, Jiasheng
Lu, Lianjun
Qiu, Jianhua
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-22، 22ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-05
دولة النشر
مصر
عدد الصفحات
22
التخصصات الرئيسية
الملخص EN
Sound conditioning (SC) is defined as “toughening” to lower levels of sound over time, which reduces a subsequent noise-induced threshold shift.
Although the protective effect of SC in mammals is generally understood, the exact mechanisms involved have not yet been elucidated.
To confirm the protective effect of SC against noise exposure (NE) and the stress-related signaling pathway of its rescue, we observed target molecule changes caused by SC of low frequency prior to NE as well as histology analysis in vivo and verified the suggested mechanisms in SGNs in vitro.
Further, we investigated the potential role of Hsp70 and Bmi1 in SC by targeting SOD1 and SOD2 which are regulated by the FoxO1 signaling pathway based on mitochondrial function and reactive oxygen species (ROS) levels.
Finally, we sought to identify the possible molecular mechanisms associated with the beneficial effects of SC against noise-induced trauma.
Data from the rat model were evaluated by western blot, immunofluorescence, and RT-PCR.
The results revealed that SC upregulated Hsp70, Bmi1, FoxO1, SOD1, and SOD2 expression in spiral ganglion neurons (SGNs).
Moreover, the auditory brainstem responses (ABRs) and electron microscopy revealed that SC could protect against acute acoustic trauma (AAT) based on a significant reduction of hearing impairment and visible reduction in outer hair cell loss as well as ultrastructural changes in OHCs and SGNs.
Collectively, these results suggested that the contribution of Bmi1 toward decreased sensitivity to noise-induced trauma following SC was triggered by Hsp70 induction and associated with enhancement of the antioxidant system and decreased mitochondrial superoxide accumulation.
This contribution of Bmi1 was achieved by direct targeting of SOD1 and SOD2, which was regulated by FoxO1.
Therefore, the Hsp70/Bmi1-FoxO1-SOD signaling pathway might contribute to the protective effect of SC against AAT in a rat model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Guoxia& Wu, Yongxiang& Qiu, Yang& Tian, Keyong& Mi, Wenjuan& Liu, Xinqin…[et al.]. 2020. Hsp70Bmi1-FoxO1-SOD Signaling Pathway Contributes to the Protective Effect of Sound Conditioning against Acute Acoustic Trauma in a Rat Model. Neural Plasticity،Vol. 2020, no. 2020, pp.1-22.
https://search.emarefa.net/detail/BIM-1202825
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Guoxia…[et al.]. Hsp70Bmi1-FoxO1-SOD Signaling Pathway Contributes to the Protective Effect of Sound Conditioning against Acute Acoustic Trauma in a Rat Model. Neural Plasticity No. 2020 (2020), pp.1-22.
https://search.emarefa.net/detail/BIM-1202825
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Guoxia& Wu, Yongxiang& Qiu, Yang& Tian, Keyong& Mi, Wenjuan& Liu, Xinqin…[et al.]. Hsp70Bmi1-FoxO1-SOD Signaling Pathway Contributes to the Protective Effect of Sound Conditioning against Acute Acoustic Trauma in a Rat Model. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-22.
https://search.emarefa.net/detail/BIM-1202825
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202825
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر