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MeHg Causes Ultrastructural Changes in Mitochondria and Autophagy in the Spinal Cord Cells of Chicken Embryo
المؤلفون المشاركون
Ferreira, Fabiana F.
Nazari, Evelise M.
Müller, Yara M. R.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Methylmercury (MeHg) is a known neurodevelopmental toxicant, which causes changes in various structures of the central nervous system (CNS).
However, ultrastructural studies of its effects on the developing CNS are still scarce.
Here, we investigated the effect of MeHg on the ultrastructure of the cells in spinal cord layers.
Chicken embryos at E3 were treated in ovo with 0.1 μg MeHg/50 μL saline solution and analyzed at E10.
Then, we used transmission electron microscopy (TEM) to identify possible damage caused by MeHg to the structures and organelles of the spinal cord cells.
After MeHg treatment, we observed, in the spinal cord mantle layer, a significant number of altered mitochondria with external membrane disruptions, crest disorganization, swelling in the mitochondrial matrix, and vacuole formation between the internal and external mitochondrial membranes.
We also observed dilations in the Golgi complex and endoplasmic reticulum cisterns and the appearance of myelin-like cytoplasmic inclusions.
We observed no difference in the total mitochondria number between the control and MeHg-treated groups.
However, the MeHg-treated embryos showed an increased number of altered mitochondria and a decreased number of mitochondrial fusion profiles.
Additionally, unusual mitochondrial shapes were found in MeHg-treated embryos as well as autophagic vacuoles similar to mitophagic profiles.
In addition, we observed autophagic vacuoles with amorphous, homogeneous, and electron-dense contents, similar to the autophagy.
Our results showed, for the first time, the neurotoxic effect of MeHg on the ultrastructure of the developing spinal cord.
Using TEM we demonstrate that changes in the endomembrane system, mitochondrial damage, disturbance in mitochondrial dynamics, and increase in mitophagy were caused by MeHg exposure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ferreira, Fabiana F.& Nazari, Evelise M.& Müller, Yara M. R.. 2018. MeHg Causes Ultrastructural Changes in Mitochondria and Autophagy in the Spinal Cord Cells of Chicken Embryo. Journal of Toxicology،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1202864
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ferreira, Fabiana F.…[et al.]. MeHg Causes Ultrastructural Changes in Mitochondria and Autophagy in the Spinal Cord Cells of Chicken Embryo. Journal of Toxicology No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1202864
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ferreira, Fabiana F.& Nazari, Evelise M.& Müller, Yara M. R.. MeHg Causes Ultrastructural Changes in Mitochondria and Autophagy in the Spinal Cord Cells of Chicken Embryo. Journal of Toxicology. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1202864
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202864
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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