Upregulation of UCP2 Expression Protects against LPS-Induced Oxidative Stress and Apoptosis in Cardiomyocytes
المؤلفون المشاركون
Zhang, Jun-liang
Huang, Jinda
Peng, Wanwan
Zheng, Yijun
Hao, Hu
Li, Sitao
Yao, Yu
Ding, Yue
Lyu, Juanjuan
Zeng, Qiyi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Uncoupling protein 2 (UCP2) has a cardioprotective role under septic conditions, but the underlying mechanism remains unclear.
This study aimed at investigating the effects of UCP2 on the oxidative stress and apoptosis of cardiomyocytes induced by lipopolysaccharide (LPS).
First, LPS increased UCP2 expression in cardiomyocytes in a time-dependent manner.
LPS increased the production of lactate dehydrogenase (LDH), reactive oxygen species (ROS), and malondialdehyde (MDA) and decreased the level of superoxide dismutase (SOD).
However, UCP2 knockdown increased the LPS-induced cardiac injury and oxidative stress.
In addition, LPS damaged the mitochondrial ultrastructure and led to the disruption of mitochondrial membrane potential (MMP), as well as the release of mitochondrial cytochrome c.
UCP2 knockdown aggravated mitochondrial injury and the release of mitochondrial cytochrome c.
LPS increased the protein levels of Bax and cleaved-caspase-3, decreased the protein level of Bcl-2, and upregulated the protein level of mitogen-activated protein kinase.
However, upon UCP2 knockdown, the protein levels of Bax and cleaved-caspase-3 increased even further, and the protein level of Bcl-2 was further decreased.
The protein level of phosphorylated p38 was also further enhanced.
Thus, UCP2 protects against LPS-induced oxidative stress and apoptosis in cardiomyocytes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Jinda& Peng, Wanwan& Zheng, Yijun& Hao, Hu& Li, Sitao& Yao, Yu…[et al.]. 2019. Upregulation of UCP2 Expression Protects against LPS-Induced Oxidative Stress and Apoptosis in Cardiomyocytes. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1202917
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Jinda…[et al.]. Upregulation of UCP2 Expression Protects against LPS-Induced Oxidative Stress and Apoptosis in Cardiomyocytes. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1202917
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Jinda& Peng, Wanwan& Zheng, Yijun& Hao, Hu& Li, Sitao& Yao, Yu…[et al.]. Upregulation of UCP2 Expression Protects against LPS-Induced Oxidative Stress and Apoptosis in Cardiomyocytes. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1202917
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202917
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر