![](/images/graphics-bg.png)
Corticosteroid Weaning in Stable Heart Transplant Patients: Guidance by Serum Cortisol Level
المؤلفون المشاركون
Baran, David A.
Rosenfeld, Cheryl
Zucker, Mark J.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Despite earlier studies describing the feasibility of steroid weaning in heart transplant patients, the majority of patients are maintained on steroid therapy for life.
We examined a strategy based on a single morning serum cortisol measurement.
Methods.
We assigned stable posttransplant patients, who were maintained on tacrolimus, mycophenolate mofetil, and corticosteroids, into one of two groups based on a screening morning cortisol level.
Patients with a cortisol < 8 micrograms/deciliter were assigned to a “maintenance” group and the others were assigned to the weaning group and steroids were tapered off over 4–6 weeks.
Patients were monitored on subsequent office visits for adrenal insufficiency and allograft rejection.
Results.
Thirty-one patients were enrolled (6 patients in the maintenance group and 25 in the steroid-weaning group).
Mean follow-up was 10.2 ± 4 years for the weaning group and 9.0 ± 4.9 years in the maintenance group ( p = 0.6 ).
No cases of rejection were noted, nor did any patient resume steroid treatment following discontinuation.
Conclusion.
Steroids can be safely discontinued in stable heart transplant patients with an AM serum cortisol ≥ 8 micrograms/deciliter with appropriate outpatient follow-up.
In this study, no patient suffered late rejection or clinically noted adrenal insufficiency.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Baran, David A.& Rosenfeld, Cheryl& Zucker, Mark J.. 2018. Corticosteroid Weaning in Stable Heart Transplant Patients: Guidance by Serum Cortisol Level. Journal of Transplantation،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203132
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Baran, David A.…[et al.]. Corticosteroid Weaning in Stable Heart Transplant Patients: Guidance by Serum Cortisol Level. Journal of Transplantation No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1203132
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Baran, David A.& Rosenfeld, Cheryl& Zucker, Mark J.. Corticosteroid Weaning in Stable Heart Transplant Patients: Guidance by Serum Cortisol Level. Journal of Transplantation. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203132
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203132
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)