Aberrant Advanced Cognitive and Attention-Related Brain Networks in Parkinson’s Disease with Freezing of Gait
المؤلفون المشاركون
Li, Mengyan
Yu, Shaode
Wei, Xinhua
Ruan, Xiuhang
Li, Yuting
Zhang, Guoqin
Du, Yuchen
Wang, Zhaoxiu
Yang, Ruimeng
Li, E.
Liu, Yanjun
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Freezing of gait (FOG) is a disabling gait disorder influencing patients with Parkinson’s disease (PD).
Accumulating evidence suggests that FOG is related to the functional alterations within brain networks.
We investigated the changes in brain resting-state functional connectivity (FC) in patients with PD with FOG (FOG+) and without FOG (FOG-).
Methods.
Resting-state functional magnetic resonance imaging (RS-fMRI) data were collected from 55 PD patients (25 FOG+ and 30 FOG-) and 26 matched healthy controls (HC).
Differences in intranetwork connectivity between FOG+, FOG-, and HC individuals were explored using independent component analysis (ICA).
Results.
Seven resting-state networks (RSNs) with abnormalities, including motor, executive, and cognitive-related networks, were found in PD patients compared to HC.
Compared to FOG- patients, FOG+ patients had increased FC in advanced cognitive and attention-related networks.
In addition, the FC values of the auditory network and default mode network were positively correlated with the Gait and Falls Questionnaire (GFQ) and Freezing of Gait Questionnaire (FOGQ) scores in FOG+ patients.
Conclusions.
Our findings suggest that the neural basis of PD is associated with impairments of multiple functional networks.
Notably, alterations of advanced cognitive and attention-related networks rather than motor networks may be related to the mechanism of FOG.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yuting& Ruan, Xiuhang& Li, E.& Zhang, Guoqin& Liu, Yanjun& Du, Yuchen…[et al.]. 2020. Aberrant Advanced Cognitive and Attention-Related Brain Networks in Parkinson’s Disease with Freezing of Gait. Neural Plasticity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1203133
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yuting…[et al.]. Aberrant Advanced Cognitive and Attention-Related Brain Networks in Parkinson’s Disease with Freezing of Gait. Neural Plasticity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1203133
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yuting& Ruan, Xiuhang& Li, E.& Zhang, Guoqin& Liu, Yanjun& Du, Yuchen…[et al.]. Aberrant Advanced Cognitive and Attention-Related Brain Networks in Parkinson’s Disease with Freezing of Gait. Neural Plasticity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1203133
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203133
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر