The Kinetics of Anti-HLA Antibodies in the First Year after Kidney Transplantation: In Whom and When Should They Be Monitored?
المؤلفون المشاركون
de Paula, Flávio J.
Castro, Maria Cristina Ribeiro de
Barbosa, Erick A.
Souza, Renata P.
Agena, Fabiana
Souza, Patrícia S. de
Maciel, Gabriella
Rodrigues, Hélcio
Panajotopoulos, Nicolas
David, Daísa S.
David-Neto, Elias
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The impact of the kinetics of the anti-HLA antibodies after KTx on the occurrence of acute rejection as well as the better time-point to monitor anti-HLA Abs after transplantation is not completely defined.
This prospective study followed 150 patients over 12 months after transplantation.
Serum IgG anti-HLA Abs were detected by single antigen beads after typing donors and recipients for loci A, B, C, DR, and DQ.
Before KTx, 89 patients did not present anti-HLA Abs and 2% developed “de novo” Abs during the 1st year, 39 patients were sensitized without DSAs, and 13% developed DSA after surgery; all of them presented ABMR.
Sensitized patients presented higher acute rejection rates (36.4% versus 13.5%, p<0.001), although 60% of the patients did not present ABMR.
Patients, in whom DSA-MFI decreased during the first two weeks after surgery, did not develop ABMR.
Those who sustained their levels presented a rate of 22% of ABMR.
85% of patients developed ABMR when MFIs increased early after transplantation (which occurred in 30% of the DSA positive patients).
In the ABMR group, we observed an iDSA-MFI sharp drop on the fourth day and then an increase between the 7th and 14th POD, which suggests DSA should be monitored at this moment in sensitized patients for better ABMR prediction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Castro, Maria Cristina Ribeiro de& Barbosa, Erick A.& Souza, Renata P.& Agena, Fabiana& Souza, Patrícia S. de& Maciel, Gabriella…[et al.]. 2018. The Kinetics of Anti-HLA Antibodies in the First Year after Kidney Transplantation: In Whom and When Should They Be Monitored?. Journal of Transplantation،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203153
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Castro, Maria Cristina Ribeiro de…[et al.]. The Kinetics of Anti-HLA Antibodies in the First Year after Kidney Transplantation: In Whom and When Should They Be Monitored?. Journal of Transplantation No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1203153
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Castro, Maria Cristina Ribeiro de& Barbosa, Erick A.& Souza, Renata P.& Agena, Fabiana& Souza, Patrícia S. de& Maciel, Gabriella…[et al.]. The Kinetics of Anti-HLA Antibodies in the First Year after Kidney Transplantation: In Whom and When Should They Be Monitored?. Journal of Transplantation. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1203153
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203153
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر